Nutritional and lipidomics biomarkers of docosahexaenoic acid-based multivitamin therapy in pediatric NASH
Torquato P, Giusepponi D, Alisi A, Galarini R, Bartolini D, Piroddi M, Goracci L, Di Veroli A, Cruciani G, Crudele A, Nobili V, Galli F
Scientific reports · 17 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Nonprofit
- Associazione Italiana per la Ricerca sul Cancro
- Nonprofit
- Fondazione Italiana per la Ricerca sul Cancro
- Grants
- Ministero dell’Istruzione, dell’Università e della Ricerca (CTN01_00230_413096)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-02-14 · Sci Rep · vol. 9 · issue 1 · p. 2045
- Publisher
- Nature Portfolio
- Cited
- 60 citations · more than 97% of similar papers · 6.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 53 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Liver Disease Diagnosis and Treatment · Diet, Metabolism, and Disease · Fatty Acid Research and Health
- Keywords
- Docosahexaenoic acid, Multivitamin, Lipidomics, Internal medicine, Arachidonic acid, Medicine, Gastroenterology, Polyunsaturated fatty acid, Docosapentaenoic acid, Randomized controlled trial, Placebo, Vitamin E, Fortified Food, Choline, Fatty acid, Vitamin, Endocrinology, Biochemistry, Biology, Pathology
- MeSH
- liver, humans, choline, vitamin e, fatty acids, omega-3, alpha-linolenic acid, docosahexaenoic acids, eicosapentaenoic acid, arachidonic acid, vitamins, vitamin d, adolescent, child, female, male, lipid metabolism, non-alcoholic fatty liver disease, biomarkers, lipidomics
12 authors
From IT
- Pierangelo TorquatoUniversity of Perugia
- Danilo GiusepponiIstituto Zooprofilattico Sperimentale dell'Umbria e delle Marche
- Anna AlisiBambino Gesù Children's Hospital
- Roberta GalariniIstituto Zooprofilattico Sperimentale dell'Umbria e delle Marche
- Desirée BartoliniUniversity of Perugia
- Marta PiroddiUniversity of Perugia
Abstract
Two recent randomized controlled trials demonstrated improved radiographic, histological and hepatometabolic cues of non-alcoholic steatohepatitis (NASH) in pediatric patients treated with the ω-3 fatty acid docosahexaenoic acid (DHA) in combination with vitamin D (VD) or with choline (CHO) and vitamin E (VE), the DHA-VD and DHA-CHO-VE trials, respectively). In the present study we verified the nutritional compliance to these DHA-based multivitamin treatments; lipidomics biomarkers of the reported outcome on NASH indicators were also investigated. Samples were obtained from 30 biopsy-proven pediatric NASH patients of the DHA-CHO-VE trial randomized in multivitamin treatment group and placebo group (n = 15 each), and from 12 patients of the treatment group of the DHA-VD trial. All patients underwent 6-month therapy plus 6 months of follow-up. Plasma samples and clinical data were obtained at baseline and at the end of the study (12 months). Selected biomarkers included the free form of DHA and other ω-3 fatty acid arachidonic acid (AA), indices of the vitamin E status, and some hepatic metabolites of these lipids. Radiographic and histological improvements of treated patients were associated with increased concentrations of DHA, α-linolenic acid and α-tocopherol (i.e. VE), and with decreased AA that was also investigated in complex lipids by untargetd lipidomics. As a result a significantly lowered AA/DHA ratio was observed to represent the main indicator of the response to the DHA-based therapy. Furthermore, baseline levels of AA/DHA showed strong association with NAS and US improvement. A stable correction of DHA AA metabolism interaction is associated with the curative effect of this therapy and may represent a key nutritional endpoint in the clinical management of pediatric NASH.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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