Funded in part by Wild Blueberry Association of North America
Circulating Anthocyanin Metabolites Mediate Vascular Benefits of Blueberries: Insights From Randomized Controlled Trials, Metabolomics, and Nutrigenomics
Rodriguez-Mateos A, Istas G, Boschek L, Feliciano RP, Mills CE, Boby C, Gomez-Alonso S, Milenkovic D, Heiss C
The journals of gerontology. Series A, Biological sciences and medical sciences · 107 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Industry funded
- University or hospital
- King's College London
- Government
- Deutsche Forschungsgemeinschaft
- University or hospital
- Menzies Centre for Australian Studies, King's College London, University of London
- University or hospital
- Medical Research Committee of the University of Dusseldorf
- Industry group
- Wild Blueberry Association of North America
- Grants
- Deutsche Forschungsgemeinschaft (SFB 1116); Deutsche Forschungsgemeinschaft (TPA07); Deutsche Forschungsgemeinschaft (SFB1116 TP A07)
Based on 5 listed funder(s).
Publication
- Published
- 2019-02-16 · J Gerontol A Biol Sci Med Sci · vol. 74 · issue 7 · pp. 967–976
- Publisher
- Oxford University Press
- Cited
- 149 citations · more than 99% of similar papers · 7.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 32 works
- Access
- Free to read
- Research areas
- Phytochemicals and Antioxidant Activities · Metabolomics and Mass Spectrometry Studies · Antioxidant Activity and Oxidative Stress
- Keywords
- Anthocyanin, Metabolomics, Nutrigenomics, Pharmacology, Chemistry, Biochemistry, Food science, Biology, Gene, Bioinformatics
- MeSH
- endothelium, vascular, animals, humans, cardiovascular diseases, anthocyanins, phytotherapy, models, animal, randomized controlled trials as topic, nutrigenomics, metabolomics, blueberry plants
9 authors
From GB, DE, FR, ES, US
- Ana Rodriguez‐Mateos · correspondingKing's College London; Heinrich Heine University Düsseldorf
- Geoffrey IstasKing's College London; Heinrich Heine University Düsseldorf
- Lisa BoschekHeinrich Heine University Düsseldorf
- Rodrigo Pedro FelicianoHeinrich Heine University Düsseldorf
- Charlotte Elizabeth MillsKing's College London; University of Reading
- Céline BobyUniversité Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Centre de Recherche en Nutrition Humaine d'Auvergne
Abstract
Potential health benefits of blueberries may be due to vascular effects of anthocyanins that predominantly circulate in blood as phenolic acid metabolites. We investigated which role blueberry anthocyanins and circulating metabolites play in mediating improvements in vascular function and explore potential mechanisms using metabolomics and nutrigenomics. Purified anthocyanins exerted a dose-dependent improvement of endothelial function in healthy humans, as measured by flow-mediated dilation. The effects were similar to those of wild blueberries containing similar amounts of anthocyanins, whereas control drinks containing fiber, minerals, or vitamins had no significant effect. Daily 1-month wild blueberry consumption increased flow-mediated dilation and lowered 24-hour ambulatory systolic blood pressure. Of the 63 anthocyanin plasma metabolites quantified, 14 and 21 correlated with acute and chronic flow-mediated dilation improvements, respectively. Injection of these metabolites improved flow-mediated dilation in mice. Daily wild blueberry consumption led to differential expression (>1.2-fold) of 608 genes and 3 microRNAs, with Mir-181c showing a 13-fold increase in peripheral blood mononuclear cells. Patterns of 13 metabolites were independent predictors of gene expression changes and pathway enrichment analysis revealed significantly modulated biological processes involved in cell adhesion, migration, immune response, and cell differentiation. Our results identify anthocyanin metabolites as major mediators of vascular bioactivities of blueberries and changes of cellular gene programs. Trial registration: NCT025208.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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