The effects of three regimens of cholecalciferol (vitamin D3) supplementation on vitamin D deficiency in non-obese and obese females
Imga NN, Berker D, Can B, Guler S
Archives of medical sciences. Atherosclerotic diseases · 7 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2018-03-27 · Arch Med Sci Atheroscler Dis · vol. 3 · issue 1 · pp. 60–67
- Publisher
- Termedia Publishing House
- Cited
- 8 citations · more than 72% of similar papers · 0.9× the field average
- References
- 34 works
- Access
- Open access (free to publish) · CC-BY-NC-SA
- Research areas
- Vitamin D Research Studies · HIV-related health complications and treatments · Nutrition and Health Studies
- Keywords
- Medicine, Regimen, Vitamin D and neurology, Internal medicine, Cholecalciferol, vitamin D deficiency, Vitamin, Endocrinology, Gastroenterology, Intramuscular injection
4 authors
From TR
- Narin Nasıroğlu İmgaAnkara Numune Eğitim ve Araştırma Hastanesi
- Dilek Sensoz BerkerAnkara Numune Eğitim ve Araştırma Hastanesi
- Bülent CanbazAnkara Numune Eğitim ve Araştırma Hastanesi
- Serdar GülerAnkara Numune Eğitim ve Araştırma Hastanesi
Abstract
Introduction
Vitamin D deficiency is a common health problem worldwide and tends to be a risk factor for all-cause mortality. We evaluated the effect of continuous low-dose oral daily and loading dose of oral weekly and loading monthly intramuscular (IM) vitamin D3 regimens on circulating levels of total 25(OH)D and in vitamin D deficient females, and between non-obese and obese subgroups.
Material and methods
A total of 231 vitamin D deficient females were included to the study. According to treatment regimen, patients were divided into three groups: daily continuous oral, loading dose of weekly oral and monthly intramuscular. All patients in treatment groups were divided into non-obese (105) and obese (126) groups. Serum 25(OH)D and parathormone (PTH) levels were evaluated at baseline and at the third and sixth month.
Results
In obese patients oral weekly loading regimen and in non-obese patients oral daily continuous regimens were found to be more potent. Baseline PTH levels decreased when compared with the third and sixth months (p p = 0.783).
Conclusions
Oral daily regimen in non-obese patients and loading weekly oral regimen in obese patients were more effective in achieving the target levels of 25(OH)D concentration above 30 ng/ml and provided a stable plasma vitamin D concentration over a long period of time.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-SA).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.