The role of oral magnesium supplements for the management of stable bronchial asthma: a systematic review and meta-analysis
Abuabat F, AlAlwan A, Masuadi E, Murad MH, Jahdali HA, Ferwana MS
NPJ primary care respiratory medicine · 7 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2019-02-18 · NPJ Prim Care Respir Med · vol. 29 · issue 1 · p. 4
- Publisher
- Nature Portfolio
- Cited
- 16 citations · more than 49% of similar papers · 0.4× the field average
- References
- 52 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Asthma and respiratory diseases · Respiratory and Cough-Related Research
- Keywords
- Medicine, Asthma, Placebo, Randomized controlled trial, Bronchodilator, Internal medicine, Meta-analysis, Quality of life (healthcare), Adverse effect, Alternative medicine, Pathology
- MeSH
- humans, asthma, magnesium, bronchodilator agents, administration, oral, dietary supplements
6 authors
From SA, US
- Faisal AbuabatKing Saud bin Abdulaziz University for Health Sciences; King Abdulaziz Medical City; King Abdullah International Medical Research Center; National Guard Health Affairs
- Abdulaziz AlalwanKing Saud bin Abdulaziz University for Health Sciences; King Abdulaziz Medical City; King Abdullah International Medical Research Center; National Guard Health Affairs
- Emad MasuadiKing Saud bin Abdulaziz University for Health Sciences; King Abdulaziz Medical City; King Abdullah International Medical Research Center; National Guard Health Affairs
- Mohammad Hassan MuradMayo Clinic
- Hamdan Al JahdaliKing Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center; National Guard Health Affairs
- Mazen Saleh Ferwana · correspondingKing Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center; National Guard Health Affairs
Abstract
Asthma is a chronic lung disease characterized by airway inflammation and hyper-responsiveness of airway smooth muscles. There is growing evidence that magnesium may have a role in managing asthma through its dual effect as an anti-inflammatory and bronchodilating agent. To assess the efficacy of oral magnesium supplements in chronic asthmatic patients. In addition to searching through Clinicaltrials.gov/ and references for oral magnesium supplement studies, we performed a database search in Medline, CINAHL, CENTRAL, and Embase. We contacted the authors of the included trials to ask for additional information. We included randomized controlled trials that compared oral magnesium supplements versus placebo, in addition to standard asthma treatment in mild-moderate asthmatic adults and children (older than 6 years). Two reviewers independently performed the study selection, data abstraction, and the assessment of the risk of bias. Eight trials at moderate risk of bias enrolling a total of 917 patients were included. Oral magnesium improved FEV1 at week 8 (5.69 (L/min); 95% CI: 1.92, 9.46; I2: 45%). There was no significant improvement in FEV1 at other follow up periods. There was no significant change in FVC, Methacholine challenge test, the frequency of bronchodilator use, or symptoms score. There were no data on mortality or quality of life. Oral magnesium supplements may lead to improvement in FEV1 that was only demonstrated at eight weeks; but no effect on any other outcome. Until future evidence emerges, oral magnesium cannot be recommended as adjuvants to standard treatment for mild to moderate asthmatic individuals.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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