Effect of caffeine on ovariectomy-induced osteoporosis in rats
Xu H, Liu T, Hu L, Li J, Gan C, Xu J, Chen F, Xiang Z, Wang X, Sheng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 40 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Major Scientific and Technological Special Project of Yunnan Province
- Government
- Young Academic and Technological Leaders of Yunnan Province
- University or hospital
- Academic Leaders of Yunnan Province
Based on 3 listed funder(s).
Publication
- Published
- 2019-02-21 · Biomed Pharmacother · vol. 112 · p. 108650
- Publisher
- Elsevier BV
- Cited
- 67 citations · more than 91% of similar papers · 2.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 52 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Bone health and treatments · Bone health and osteoporosis research · Cancer Risks and Factors
- Keywords
- Ovariectomized rat, Caffeine, Endocrinology, Internal medicine, Osteoporosis, Raloxifene, Alkaloid, Xanthine, Calcium, Medicine, Bone mineral, In vivo, Chemistry, Estrogen, Biology, Estrogen receptor, Biochemistry
- MeSH
- animals, humans, rats, rats, wistar, osteoporosis, postmenopausal, caffeine, phosphodiesterase inhibitors, organ size, ovariectomy, bone density, dose-response relationship, drug, female, lipid metabolism
10 authors
From CN
- Huanhuan XuYunnan Agricultural University; Tea Research Institute
- Titi LiuYunnan Agricultural University; Tea Research Institute
- Lihong HuYunnan Agricultural University; Tea Research Institute
- Li JinYunnan Agricultural University; Tea Research Institute
- Chunxia GanYunnan Agricultural University; Tea Research Institute
- Jing XuYunnan Agricultural University; Tea Research Institute
Abstract
Caffeine (1,3,7-trimethylxanthine) is a naturally occurring plant xanthine alkaloid present in many commonly consumed beverages worldwide, including tea, coffee, and cocoa. Although moderate caffeine intake is generally considered to exert positive effects on human health, its effect on bone metabolism remains controversial. The aim of this study was to systematically evaluate the pharmacological effect of long-term administration of caffeine on ovariectomy-induced postmenopausal osteoporosis in female rats. A sham operation or ovariectomy was performed to establish the ovariectomy rat model. The ovariectomized (OVX) rats were divided into five subgroups: OVX with vehicle (model), OVX with raloxifene hydrochloride (RLX, positive control; 4 mg/kg body weight/day), and OVX with low-, medium-, and high-dose caffeine (9.6, 19.2, and 38.4 mg/kg of body weight/day, respectively). Their corresponding treatments were administered intragastrically for 13 weeks. In-vivo studies showed that treatment with caffeine effectively improved the lipid profiles and increased the concentration of calcium in the serum of OVX rats. Medium- or high-dose treatment with caffeine significantly decreased the activities of alkaline and acid phosphatases in OVX rats. In addition, treatment with caffeine (at any dose) did not adversely affect organ weights, organ coefficients, femoral length, bone mineral density, biomechanical properties, or bone microarchitecture in OVX rats. Collectively, our study demonstrated that caffeine did not exert a damaging effect on the skeletal system of OVX rats.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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