Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption
Acevedo N, Frumento P, Harb H, Alashkar Alhamwe B, Johansson C, Eick L, Alm J, Renz H, Scheynius A, Potaczek DP
International journal of molecular sciences · 36 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Possibly industry funded
- Nonprofit
- Von-Behring-Röntgen-Stiftung
- Nonprofit
- Vårdalstiftelsen
- Nonprofit
- Insamlingsstiftelsen Cancer- och Allergifonden
- University or hospital
- Karolinska Institutet
- Government
- Vetenskapsrådet
- Nonprofit
- Svenska Läkaresällskapet
- University or hospital
- Deutsches Zentrum für Lungenforschung
- Nonprofit
- Ekhagastiftelsen
- University or hospital
- the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and the Karolinska Institutet and the Karolinska University Hospital
- Nonprofit
- Hesselman Foundation
- University or hospital
- Universities Giessen and Marburg Lung Centre
- Nonprofit
- Swedish Asthma and Allergy Research Association
- Nonprofit
- Vårdal Foundation
- Government
- Swedish Research Council for Working Life and Social Research
- Nonprofit
- Frimurare Barnhuset Foundation in Stockholm
- Industry group
- Mjölkdroppen Society
- Government
- Swedish Research Council
- Government
- German Academic Exchange Service: DAAD
- Nonprofit
- Cancer and Allergy Fund
- Nonprofit
- Ekhaga Foundation
- Nonprofit
- Swedish Society of Medicine
- University or hospital
- German Center for Lung Research (DZL)
- University or hospital
- Centre for Allergy Research Karolinska Institutet
- Nonprofit
- King Gustaf V:s 80-årsfond
- Nonprofit
- Von Behring-Röntgen-Foundation (Von Behring-Röntgen-Stiftung)
- Nonprofit
- Samariten Foundation
- Grants
- Deutsches Zentrum für Lungenforschung (62-LV04); Von-Behring-Röntgen-Stiftung (62-LV04); Deutsches Zentrum für Lungenforschung (FAA-2015-0151); Deutsches Zentrum für Lungenforschung (2006-1630); Deutsches Zentrum für Lungenforschung (personal reference number: 91559386); Vetenskapsrådet (2012-03011); Deutsches Zentrum für Lungenforschung (82DZL00502/A2)
Based on 26 listed funder(s).
Publication
- Published
- 2019-03-01 · Int J Mol Sci · vol. 20 · issue 5 · p. 1060
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 54 citations · more than 92% of similar papers · 2.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 36 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Epigenetics and DNA Methylation · Birth, Development, and Health · Infant Nutrition and Health
- Keywords
- Offspring, Chromatin immunoprecipitation, Biology, Acetylation, Pregnancy, Epigenetics, Fish oil, Immune system, Histone, Internal medicine, Andrology, Endocrinology, Immunology, Gene, Genetics, Medicine, Gene expression, Fish <Actinopterygii>, Promoter, Fishery
- MeSH
- placenta, humans, protein kinase c, fish oils, t-box domain proteins, receptors, interleukin, histones, interleukin-13, protein processing, post-translational, acetylation, pregnancy, fish products, female, immunity, innate, maternal nutritional physiological phenomena, olive oil, lipopolysaccharide receptors, t-bet transcription factor, protein kinase c zeta
10 authors
From CO, SE, US, DE, SY, PL
- Nathalie AcevedoUniversity of Cartagena; Karolinska Institutet; Stockholm South General Hospital; Sachs' Children and Youth Hospital
- Paolo FrumentoKarolinska Institutet
- Hani HarbBoston Children's Hospital; Harvard University; German Center for Lung Research; Universities of Giessen and Marburg Lung Center
- Bilal Alashkar AlhamweGerman Center for Lung Research; Universities of Giessen and Marburg Lung Center; International University for Science and Technology
- Catharina JohanssonKarolinska Institutet; Stockholm South General Hospital; Sachs' Children and Youth Hospital
- Lisa EickGerman Center for Lung Research; Universities of Giessen and Marburg Lung Center
Abstract
Maternal diet modifies epigenetic programming in offspring, a potentially critical factor in the immune dysregulation of modern societies. We previously found that prenatal fish oil supplementation affects neonatal T-cell histone acetylation of genes implicated in adaptive immunity including PRKCZ, IL13, and TBX21. In this study, we measured H3 and H4 histone acetylation levels by chromatin immunoprecipitation in 173 term placentas collected in the prospective birth cohort, ALADDIN, in which information on lifestyle and diet is thoroughly recorded. In anthroposophic families, regular olive oil usage during pregnancy was associated with increased H3 acetylation at FOXP3 (p = 0.004), IL10RA (p = 0.008), and IL7R (p = 0.007) promoters, which remained significant after adjustment by offspring gender. Furthermore, maternal fish consumption was associated with increased H4 acetylation at the CD14 gene in placentas of female offspring (p = 0.009). In conclusion, prenatal olive oil intake can affect placental histone acetylation in immune regulatory genes, confirming previously observed pro-acetylation effects of olive oil polyphenols. The association with fish consumption may implicate ω-3 polyunsaturated fatty acids present in fish oil. Altered histone acetylation in placentas from mothers who regularly include fish or olive oil in their diets could influence immune priming in the newborn.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.