Interaction between an ATP-Binding Cassette A1 (ABCA1) Variant and Egg Consumption for the Risk of Ischemic Stroke and Carotid Atherosclerosis: a Family-Based Study in the Chinese Population
Song J, Jiang X, Cao Y, Juan J, Wu T, Hu Y
Journal of atherosclerosis and thrombosis · 9 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Grants
- National Natural Science Foundation of China (81573226); National Natural Science Foundation of China (81102177); National Natural Science Foundation of China (81172744); National Natural Science Foundation of China (81230066)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-02-28 · J Atheroscler Thromb · vol. 26 · issue 9 · pp. 835–845
- Publisher
- Japan Atherosclerosis Society
- Cited
- 12 citations · more than 86% of similar papers · 2.1× the field average
- References
- 63 works
- Access
- Open access (free to publish) · CC-BY-NC-SA
- Research areas
- Cholesterol and Lipid Metabolism · Lipoproteins and Cardiovascular Health · Fatty Acid Research and Health
- Keywords
- Medicine, Odds ratio, ABCA1, Confidence interval, Stroke (engine), Logistic regression, Internal medicine, Cardiology, Population, Cholesterol, Biology, Genetics, Gene, Environmental health
- MeSH
- humans, brain ischemia, carotid artery diseases, prognosis, diet, case-control studies, follow-up studies, eggs, middle aged, female, male, stroke, atp binding cassette transporter 1, asian people
6 authors
From CN, SE
- Jing SongPeking University
- Xia JiangKarolinska Institutet
- Yaying CaoPeking University
- Juan JuanPeking University; Peking University First Hospital
- Tao WuPeking University
- Yonghua HuPeking University
Abstract
Aim
ATP-binding cassette A1 (ABCA1) plays an important role in reducing the risk of stroke. Egg is the major source of dietary cholesterol and is known to be associated with the risk of stroke and atherosclerosis. We aimed to assess the effects of interaction between an ABCA1 variant (rs2066715) and egg consumption on the risk of ischemic stroke (IS), carotid plaque, and carotid-intima media thickness (CIMT) in the Chinese population.
Methods
In total, 5869 subjects (including 1213 IS cases) across 1128 families were enrolled and divided into two groups based on the median egg consumption (4 eggs per week). In the analyses for the presence of carotid plaque and CIMT, 3171 out of 4656 IS-free controls without self-reported history of coronary heart disease and lipid-lowering medications were included. Multilevel logistic regression models were used to model the genetic association of rs2066715 with the risk of IS, and mixed-effect linear regression for the genetic association of rs2066715 with carotid plaque, and CIMT. The gene-by-egg cross-product term was included in the regression model for interaction analysis.
Results
We found that rs2066715 was associated with the increased risk of carotid plaque among those who consumed ＜4 eggs per week after adjustment (odds ratio [95% confidence interval]: 1.61 [1.08, 2.39], P =0.019). A significant effect of interaction between rs2066715 and egg consumption on the risk of carotid plaque was identified (P =0.011).
Conclusion
rs2066715 was found to interact with egg consumption in modifying the risk of carotid plaque in the Chinese population.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-SA).
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