Funded in part by Nestec
Animal foods and postmenopausal breast cancer risk: a prospective cohort study
Marcondes LH, Franco OH, Ruiter R, Ikram MA, Mulder M, Stricker BH, Kiefte-de Jong JC
The British journal of nutrition · 11 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Industry funded
- Nonprofit
- American Institute for Cancer Research
- Company
- Nestec
Based on 2 listed funder(s).
Publication
- Published
- 2019-03-04 · Br J Nutr · vol. 122 · issue 5 · pp. 583–591
- Publisher
- Cambridge University Press
- Cited
- 21 citations · more than 91% of similar papers · 3.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 49 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Cancer Risks and Factors · Colorectal Cancer Screening and Detection
- Keywords
- Breast cancer, Medicine, Prospective cohort study, Hazard ratio, Proportional hazards model, Cancer, Cohort study, Confounding, Red meat, Lower risk, Risk factor, Physiology, Population, Environmental health, Internal medicine, Oncology, Confidence interval, Pathology
- MeSH
- humans, breast neoplasms, diet, risk factors, cohort studies, prospective studies, postmenopause, dairy products, eggs, meat products, aged, female
7 authors
From NL
- Larissa MarcondesErasmus MC; Erasmus University Rotterdam
- Oscar H. FrancoErasmus MC; Erasmus University Rotterdam
- Rikje RuiterErasmus MC; Erasmus University Rotterdam
- M. Arfan IkramErasmus MC; Erasmus University Rotterdam
- Marlies MulderErasmus MC; Erasmus University Rotterdam
- Bruno H. Ch. StrickerErasmus MC; Erasmus University Rotterdam
Abstract
The role of diet on breast cancer risk is not well elucidated but animal food sources may play a role through, for example, the pathway of the insulin-like growth factor 1 system or cholesterol metabolism. The aim of this study was to evaluate the association between animal foods and the risk of postmenopausal breast cancer. This study was embedded in the Rotterdam Study, a population-based prospective cohort study of subjects aged 55 years and over (61 % female). Dietary intake of different animal foods was assessed at baseline using a validated FFQ and adjusted for energy intake using the residual method. We performed Cox proportional hazards modelling to analyse the association between the intake of the different food sources and breast cancer risk after adjustment for socio-demographic, lifestyle and metabolic factors. During a median follow-up of 17 years, we identified 199 cases of breast cancer (6·2 %) among 3209 women. After adjustment for multiple confounders, no consistent association was found between the intake of red meat intake, poultry, fish or dairy products and breast cancer risk. However, we found that egg intake was significantly associated with a higher risk of breast cancer (hazard ratioQ4 v. Q1: 1·83; 95 % CI 1·20, 2·79; Ptrend=0·01). In conclusion, this study found that dietary egg intake but no other animal foods was associated with a higher risk of postmenopausal breast cancer. Further research on the potential mechanisms underlying this association is warranted.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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