The Impact of Intermittent Fasting (Ramadan Fasting) on Psoriatic Arthritis Disease Activity, Enthesitis, and Dactylitis: A Multicentre Study
Adawi M, Damiani G, Bragazzi NL, Bridgewood C, Pacifico A, Conic RRZ, Morrone A, Malagoli P, Pigatto PDM, Amital H, McGonagle D, Watad A
Nutrients · 66 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2019-03-12 · Nutrients · vol. 11 · issue 3 · p. 601
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 88 citations · more than 94% of similar papers · 3.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 37 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Psoriasis: Treatment and Pathogenesis · Dietary Effects on Health · Dermatology and Skin Diseases
- Keywords
- Dactylitis, Enthesitis, Medicine, Psoriatic arthritis, Ankylosing spondylitis, Internal medicine, Psoriasis, Psoriasis Area and Severity Index, Body mass index, BASDAI, Gastroenterology, Arthritis, Immunology
- MeSH
- humans, arthritis, psoriatic, fasting, islam, adult, middle aged, female, male
12 authors
From IL, IT, US, GB
- Mohammad AdawiBar-Ilan University
- Giovanni Battista DamianiCentro Studi GISED; University of Milan; IRCCS Ospedale Galeazzi - Sant'Ambrogio; Case Western Reserve University
- Nicola Luigi Bragazzi · correspondingUniversity of Genoa
- Charlie BridgewoodUniversity of Leeds; Leeds Teaching Hospitals NHS Trust; NIHR Leeds Musculoskeletal Biomedical Research Unit
- Alessia PacificoSan Gallicano Hospital; Istituti di Ricovero e Cura a Carattere Scientifico
- Rosalynn R.Z. ConicCase Western Reserve University
Abstract
Intermittent circadian fasting, namely Ramadan, is a common worldwide practice. Such fasting has a positive impact on psoriasis, but no data exist on its role in psoriatic arthritis (PsA)-a disease that is clearly linked to body mass index. We enrolled 37 patients (23 females and 14 males) with a mean age 43.32 ± 7.81 and they fasted for 17 h for one month in 2016. The baseline PsA characteristics were collected and 12 (32.4%) patients had peripheral arthritis, 13 (35.1%) had axial involvement, 24 (64.9%) had enthesitis, and 13 (35.1%) had dactylitis. Three patients (8.1%) were treated with methotrexate, 28 (75.7%) with TNF-α blockers, and 6 (16.2%) with IL-17 blockers. After a month of intermittent fasting, C-reactive protein (CRP) levels decreased from 14.08 ± 4.65 to 12.16 ± 4.46 (p p = 0.0078), Psoriasis Area Severity Index (PASI) decreased from 7.46 ± 2.43 to 5.86 ± 2.37 (p p p p = 0.0001). Fasting was found to be a predictor of a decrease in PsA disease activity scores (DAPSA, BASDAI, LEI, DSS) even after adjustment for weight loss. IL-17 therapy was found to be an independent predictor of decreases in LEI after fasting. These preliminary data may support the use of chronomedicine in the context of rheumatic diseases, namely PsA. Further studies are needed to support our findings.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.