Canolol Dimer, a Biologically Active Phenolic Compound of Edible Rapeseed Oil
Kraljić K, Brkan V, Škevin D, Srček VG, Radošević K
Lipids · 13 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- Hrvatska Zaklada za Znanost
- Government
- Croatian Science Foundation
Based on 2 listed funder(s).
Publication
- Published
- 2019-02-01 · Lipids · vol. 54 · issue 2-3 · pp. 189–200
- Publisher
- Wiley
- Cited
- 33 citations · more than 71% of similar papers · 0.9× the field average
- References
- 34 works
- Access
- Paywalled
- Research areas
- Genomics, phytochemicals, and oxidative stress · Free Radicals and Antioxidants · Phytochemicals and Antioxidant Activities
- Keywords
- Dimer, Chemistry, Rapeseed, Antioxidant, HeLa, Food science, Organic chemistry, Biochemistry, In vitro
- MeSH
- hela cells, humans, brassica rapa, phenols, plant oils, antioxidants, chromatography, high pressure liquid, cell survival, mcf-7 cells
5 authors
From HR, GB
- Klara KraljićUniversity of Zagreb
- Veronika BrkanUniversity of Zagreb; BioTransformations (United Kingdom)
- Dubravka ŠkevinUniversity of Zagreb
- Višnja Gaurina SrčekUniversity of Zagreb; BioTransformations (United Kingdom)
- Kristina Radošević · correspondingUniversity of Zagreb; BioTransformations (United Kingdom)
Abstract
Rapeseed and its oil are the source of many biologically active substances. From crude rapeseed oil, canolol is isolated and from edible oil its dimer. Herein, we tested the biological activity of those two compounds isolated from the oils by determining their antioxidant capacity and in vitro cytotoxicity on human tumor cell lines. Canolol and its dimer showed antiproliferative activity on both cell lines with IC50 values of 46.45 μM in HeLa, and 51.19 μM in MCF7 cells, respectively. Evaluation of cell death was also done, while the oxygen radical absorbance capacity method confirmed that the canolol dimer has higher antioxidant potential than canolol. Stability of canolol and its dimer under different storage conditions showed that for a longer period of time both compounds should be stored in a freezer, but also that the dimer is more stable against degradation than canolol. Presented results indicate possible applications of canolol and its dimer in the food and pharmaceutical industry as a natural antioxidant and an anticancer agent, respectively.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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