Dietary nitrate intake is associated with muscle function in older women
Sim M, Lewis JR, Blekkenhorst LC, Bondonno CP, Devine A, Zhu K, Peeling P, Prince RL, Hodgson JM
Journal of cachexia, sarcopenia and muscle · 30 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- University or hospital
- Royal Perth Hospital Medical Research Foundation
- Government
- Healthway
- Government
- Medical Research Council
- Government
- National Health and Medical Research Council
- Grants
- National Health and Medical Research Council (572604); National Health and Medical Research Council (254627, 303169 and 572604); National Health and Medical Research Council (303169); Healthway (572604); National Health and Medical Research Council (1107474); Healthway (254627); Healthway (303169); National Health and Medical Research Council (254627)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-03-24 · J Cachexia Sarcopenia Muscle · vol. 10 · issue 3 · pp. 601–610
- Publisher
- Springer Science+Business Media
- Cited
- 36 citations · more than 85% of similar papers · 1.9× the field average
- References
- 47 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Nitric Oxide and Endothelin Effects · Exercise and Physiological Responses · Muscle Physiology and Disorders
- Keywords
- Medicine, Nitrate, Logistic regression, Dietary Nitrate, Animal science, Grip strength, Dietary Reference Intake, Cross-sectional study, Internal medicine, Physiology, Nutrient, Ecology, Nitrite, Biology, Pathology
- MeSH
- humans, vegetables, nitrates, hand strength, nutrition assessment, cross-sectional studies, feeding behavior, aging, dietary supplements, aged, australia, female, independent living
9 authors
From AU
- Marc Sim · correspondingEdith Cowan University; Royal Perth Hospital
- Joshua Richard LewisEdith Cowan University; The University of Sydney; Royal Perth Hospital; Children's Hospital at Westmead
- Lauren C. BlekkenhorstEdith Cowan University; Royal Perth Hospital
- Catherine P. BondonnoEdith Cowan University; Royal Perth Hospital
- Amanda DevineEdith Cowan University
- Kun ZhuSir Charles Gairdner Hospital
Abstract
Background
In younger individuals, dietary nitrate supplementation has been shown to improve short-term vascular and muscle function. The role of higher habitual nitrate intake as part of a typical diet on muscle function in ageing has not been investigated. A cross-sectional study of relationships between dietary nitrate and measures of muscle function in older community-dwelling Australian women (n = 1420, ≥70 years) was undertaken.
Methods
Participants completed a semi-quantitative food frequency questionnaire assessing dietary intake over the previous year. Total nitrate from vegetables and non-vegetable sources was calculated from a validated instrument that quantified the nitrate content of food recorded within the food frequency questionnaire. Handgrip strength and timed-up-and-go (TUG) were assessed, representing muscle strength and physical function, respectively. Cut-points for weak grip strength (10.2 s) were selected due to their association with adverse outcomes. Linear and logistic regressions were used to examine the relationship between total nitrate intake and muscle function measures.
Results
Mean ± standard deviation (SD) total nitrate intake was 79.5 ± 31.2 mg/day, of which 84.5% came from vegetables. Across the unadjusted tertiles of nitrate intake (10.2 s) was 61.0% and 36.9%, respectively. Each SD higher nitrate intake (31.2 mg/day) was associated with lower odds for weak grip strength (OR 0.84, 95% CI 0.74-0.95, P = 0.005) and slow TUG (OR 0.86, 95% CI 0.76-0.98, P = 0.021). Compared with women in the lowest tertile of nitrate intake, women in the highest nitrate intake tertile had lower odds for weak grip strength (OR 0.65, 95% CI 0.49-0.87, Ptrend= 0.004) and slow TUG (OR 0.72, 95% CI 0.53-0.97, Ptrend = 0.044).
Conclusions
This investigation highlights potential benefits of nitrate-rich diets on muscle strength and physical function in a large cohort of older women. Considering poor muscle strength and physical function is associated with a range of adverse health outcomes such as falling, fractures, cardiovascular disease, and mortality, increasing dietary nitrate, especially though vegetable consumption may be an effective way to limit age-related declines in muscle function.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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