Direct and indirect associations between dietary magnesium intake and breast cancer risk
Huang WQ, Long WQ, Mo XF, Zhang NQ, Luo H, Lin FY, Huang J, Zhang CX
Scientific reports · 28 citations
How it was studied
- Design
- Case-control study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-04-08 · Sci Rep · vol. 9 · issue 1 · p. 5764
- Publisher
- Nature Portfolio
- Cited
- 41 citations · more than 87% of similar papers · 2.3× the field average
- References
- 79 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Biomarkers in Disease Mechanisms · Parathyroid Disorders and Treatments
- Keywords
- Medicine, Breast cancer, Odds ratio, Confidence interval, Case-control study, Internal medicine, Cancer, Logistic regression, C-reactive protein, Oncology, Gastroenterology, Inflammation
- MeSH
- humans, breast neoplasms, magnesium, c-reactive protein, interleukin-6, diet, adult, aged, middle aged, female, surveys and questionnaires
8 authors
From CN
- Wuqing HuangSun Yat-sen University
- Weiqing LongSun Yat-sen University; The First Affiliated Hospital, Sun Yat-sen University
- Xiong‐Fei MoSun Yat-sen University; The First Affiliated Hospital, Sun Yat-sen University
- Naiqi ZhangSun Yat-sen University
- Hong L LuoSun Yat-sen University
- Fang‐Yu LinSun Yat-sen University; The First Affiliated Hospital, Sun Yat-sen University
Abstract
This study aimed to explore the effect of dietary magnesium intake on breast cancer risk both directly and indirectly via its effect on inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6). This case-control study recruited 1050 case patients and 1229 control subjects. Inflammatory marker levels of 322 cases and 322 controls, randomly selected, were measured using ELISA, and data on dietary magnesium intake were collected using a food frequency questionnaire. Multivariable logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (CI), and path analysis was used to investigate the mediating effect. A higher magnesium intake was associated with a lower breast cancer risk (adjusted OR = 0.80, 95% CI = 0.65, 0.99). A positive association was found between the CRP level and breast cancer risk (adjusted OR = 1.43, 95% CI = 1.02-2.01). However, IL-6 was not found to be associated with breast cancer risk. Path analysis revealed that dietary magnesium affected breast cancer risk both directly and indirectly by influencing the CRP level. The results indicate that a direct negative association and an indirect association through influencing the CRP level were observed between dietary magnesium intake and breast cancer risk.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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