Prospective association between ultra-processed food consumption and incident depressive symptoms in the French NutriNet-Santé cohort
Adjibade M, Julia C, Allès B, Touvier M, Lemogne C, Srour B, Hercberg S, Galan P, Assmann KE, Kesse-Guyot E
BMC medicine · 146 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Fondation pour la Recherche Médicale
- Nonprofit
- Fondation ARC pour la Recherche sur le Cancer
- Authors
- At least one author declares a financial tie to industry
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-04-15 · BMC Med · vol. 17 · issue 1 · p. 78
- Publisher
- BioMed Central
- Cited
- 225 citations · more than 100% of similar papers · 20.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 53 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Consumer Attitudes and Food Labeling · Nutrition, Genetics, and Disease · Nutritional Studies and Diet
- Keywords
- Medicine, Hazard ratio, Confidence interval, Prospective cohort study, Confounding, Cohort, Body mass index, Depression (economics), Proportional hazards model, Cohort study, Center for Epidemiologic Studies Depression Scale, Environmental health, Depressive symptoms, Pediatrics, Demography, Internal medicine, Psychiatry, Anxiety
- MeSH
- humans, diet, cohort studies, prospective studies, depression, adolescent, adult, aged, aged, 80 and over, middle aged, france, female, male, young adult, fast foods
10 authors
From FR
- Moufidath Adjibade · correspondingInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Equipe de Recherche en Epidémiologie Nutritionnelle; Centre de Recherche Épidémiologie et Statistique
- Chantal JuliaInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Hôpital Avicenne; Equipe de Recherche en Epidémiologie Nutritionnelle; Centre de Recherche Épidémiologie et Statistique
- Benjamin AllèsInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Equipe de Recherche en Epidémiologie Nutritionnelle; Centre de Recherche Épidémiologie et Statistique
- Mathilde TouvierInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Equipe de Recherche en Epidémiologie Nutritionnelle; Centre de Recherche Épidémiologie et Statistique
- Cédric LemogneDélégation Paris 5; Inserm; Université Paris Cité; Sorbonne Paris Cité; Assistance Publique – Hôpitaux de Paris; Hôpital Européen; Institut de Psychiatrie et Neurosciences de Paris
- Bernard SrourInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Equipe de Recherche en Epidémiologie Nutritionnelle; Centre de Recherche Épidémiologie et Statistique
Abstract
Background
Ultra-processed food (UPF) consumption has increased over the last decades in Westernized countries. Our objective was to investigate for the first time the association between the proportion of UPF (%UPF) in the diet and incident depressive symptoms in the NutriNet-Santé cohort.
Methods
The sample included 20,380 women and 6350 men (aged 18-86 years) without depressive symptoms at the first Center for Epidemiologic Studies Depression Scale (CES-D) measurement, using validated cut-offs (CES-D score ≥ 17 for men and ≥ 23 for women). The proportion of UPF in the diet was computed for each subject using the NOVA classification applied to dietary intakes collected by repeated 24-h records (mean = 8; SD = 2.3). The association between UPF and depressive symptoms was evaluated using multivariable Cox proportional hazards models.
Results
Over a mean follow-up of 5.4 years, 2221 incident cases of depressive symptoms were identified. After accounting for a wide range of potential confounders, an increased risk of depressive symptoms was observed with an increased %UPF in the diet. In the main model adjusted for sociodemographic characteristics, body mass index, and lifestyle factors, the estimated hazard ratio for a 10% increase in UPF was 1.21 (95% confidence interval = 1.15-1.27). Considering %UPF in food groups, the association was significant only for beverages and sauces or added fats.
Conclusion
Overall, UPF consumption was positively associated with the risk of incident depressive symptoms, suggesting that accounting for this non-nutritional aspect of the diet could be important for mental health promotion.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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