Diet and colorectal cancer in UK Biobank: a prospective study
Bradbury KE, Murphy N, Key TJ
International journal of epidemiology · 202 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- World Health Organization
- Nonprofit
- Wellcome Trust
- Nonprofit
- Cancer Research UK
- Government
- Medical Research Council
- Government
- Girdlers’ New Zealand Health Research Council
- Nonprofit
- Livestock, Environment and People
- Grants
- Medical Research Council (M012190/1); Medical Research Council (MR/M012190); Medical Research Council (C8221/A19170); Medical Research Council (MR/M012190/1); Wellcome Trust (C8221/A19170); Wellcome Trust (205212); Medical Research Council (MR/M012190/1); Cancer Research UK (MR/M012190/1); Cancer Research UK (C8221/A19170); Cancer Research UK (A16491); Cancer Research UK (570/A16491); Cancer Research UK (A19170); Wellcome Trust (205212/Z/16/Z); Wellcome Trust (MR/M012190/1)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-03-29 · Int J Epidemiol · vol. 49 · issue 1 · pp. 246–258
- Publisher
- Oxford University Press
- Cited
- 295 citations · more than 100% of similar papers · 24.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 28 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Colorectal Cancer Screening and Detection · Alcohol Consumption and Health Effects
- Keywords
- Medicine, Colorectal cancer, Red meat, Hazard ratio, Confidence interval, Proportional hazards model, Cancer, Biobank, Prospective cohort study, Lower risk, Environmental health, Demography, Internal medicine, Biology, Bioinformatics
- MeSH
- animals, poultry, humans, fruit, vegetables, colorectal neoplasms, diet, proportional hazards models, risk factors, prospective studies, feeding behavior, dietary fiber, meat, seafood, adult, aged, middle aged, biological specimen banks, female, male, united kingdom
3 authors
From NZ, GB, FR
- Kathryn Erica Bradbury · correspondingUniversity of Auckland; University of Oxford
- Neil MurphyCentre international de recherche sur le cancer
- Timothy J. KeyUniversity of Oxford
Abstract
Background
Most of the previous studies on diet and colorectal cancer were based on diets consumed during the 1990s.
Methods
We used Cox-regression models to estimate adjusted hazard ratios for colorectal cancer by dietary factors in the UK Biobank study. Men and women aged 40-69 years at recruitment (2006-10) reported their diet on a short food-frequency questionnaire (n = 475 581). Dietary intakes were re-measured in a large sub-sample (n = 175 402) who completed an online 24-hour dietary assessment during follow-up. Trends in risk across the baseline categories were calculated by assigning re-measured intakes to allow for measurement error and changes in intake over time.
Results
During an average of 5.7 years of follow-up, 2609 cases of colorectal cancer occurred. Participants who reported consuming an average of 76 g/day of red and processed meat compared with 21 g/day had a 20% [95% confidence interval (CI): 4-37] higher risk of colorectal cancer. Participants in the highest fifth of intake of fibre from bread and breakfast cereals had a 14% (95% CI: 2-24) lower risk of colorectal cancer. Alcohol was associated with an 8% (95% CI: 4-12) higher risk per 10 g/day higher intake. Fish, poultry, cheese, fruit, vegetables, tea and coffee were not associated with colorectal-cancer risk.
Conclusions
Consumption of red and processed meat at an average level of 76 g/d that meets the current UK government recommendation (≤90 g/day) was associated with an increased risk of colorectal cancer. Alcohol was also associated with an increased risk of colorectal cancer, whereas fibre from bread and breakfast cereals was associated with a reduced risk.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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