Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial
Hutchison AT, Regmi P, Manoogian ENC, Fleischer JG, Wittert GA, Panda S, Heilbronn LK
Obesity (Silver Spring, Md.) · 334 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Royal Adelaide Hospital
- Grants
- Royal Adelaide Hospital (561110093)
Based on 1 listed funder(s).
Publication
- Published
- 2019-04-19 · Obesity (Silver Spring) · vol. 27 · issue 5 · pp. 724–732
- Publisher
- Wiley
- Cited
- 473 citations · more than 100% of similar papers · 32.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 37 works
- Access
- Paywalled
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Sleep and related disorders
- Keywords
- Postprandial, Medicine, Internal medicine, Glycemic, Type 2 diabetes, Crossover study, Endocrinology, Meal, Area under the curve, Insulin, Diabetes mellitus, Placebo
- MeSH
- humans, diabetes mellitus, type 2, fasting, risk factors, cross-over studies, middle aged, male
7 authors
From AU, US
- Amy T. HutchisonSouth Australian Health and Medical Research Institute; National Health and Medical Research Council; The University of Adelaide
- Prashant RegmiSouth Australian Health and Medical Research Institute; National Health and Medical Research Council; The University of Adelaide
- Emily N. C. ManoogianSalk Institute for Biological Studies
- Jason G. FleischerSalk Institute for Biological Studies
- Gary WittertSouth Australian Health and Medical Research Institute; National Health and Medical Research Council; The University of Adelaide
- Satchidananda PandaSalk Institute for Biological Studies
Abstract
Objective
This study aimed to assess the effects of 9-hour time-restricted feeding (TRF), early (TRFe) or delayed (TRFd), on glucose tolerance in men at risk for type 2 diabetes.
Methods
Fifteen men (age 55 ± 3 years, BMI 33.9 ± 0.8 kg/m2 ) wore a continuous glucose monitor for 7 days of baseline assessment and during two 7-day TRF conditions. Participants were randomized to TRFe (8 am to 5 pm) or TRFd (12 pm to 9 pm), separated by a 2-week washout phase. Glucose, insulin, triglycerides, nonesterified fatty acids, and gastrointestinal hormone incremental areas under the curve were calculated following a standard meal on days 0 and 7 at 8 am (TRFe) or 12 pm (TRFd).
Results
TRF improved glucose tolerance as assessed by a reduction in glucose incremental area under the curve (P = 0.001) and fasting triglycerides (P = 0.003) on day 7 versus day 0. However, there were no mealtime by TRF interactions in any of the variables examined. There was also no effect of TRF on fasting and postprandial insulin, nonesterified fatty acids, or gastrointestinal hormones. Mean fasting glucose by continuous glucose monitor was lower in TRFe (P = 0.02) but not TRFd (P = 0.17) versus baseline, but there was no difference between TRF conditions.
Conclusions
While only TRFe lowered mean fasting glucose, TRF improved glycemic responses to a test meal in men at risk for type 2 diabetes regardless of the clock time that TRF was initiated.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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