Pulsed Near Infrared Transcranial and Intranasal Photobiomodulation Significantly Modulates Neural Oscillations: a pilot exploratory study
Zomorrodi R, Loheswaran G, Pushparaj A, Lim L
Scientific reports · 109 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Authors
- At least one author declares a financial tie to industry
Based on full-text disclosure statement.
Publication
- Published
- 2019-04-19 · Sci Rep · vol. 9 · issue 1 · p. 6309
- Publisher
- Nature Portfolio
- Cited
- 168 citations · more than 99% of similar papers · 10.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 59 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Laser Applications in Dentistry and Medicine · Photoreceptor and optogenetics research · Migraine and Headache Studies
- Keywords
- Electroencephalography, Neuroscience, Checkerboard, Default mode network, Stimulation, Transcranial alternating current stimulation, Phase lag, Transcranial magnetic stimulation, Near-infrared spectroscopy, Medicine, Audiology, Biomedical engineering, Functional connectivity, Psychology, Biology, Mathematics
- MeSH
- brain, nerve net, humans, cross-over studies, double-blind method, aged, middle aged, female, male, brain waves
4 authors
From CA
- Reza Zomorrodi · correspondingCentre for Addiction and Mental Health
- Genane Loheswaran
- Abhiram P. Pushparaj
- Lew Lim
Abstract
Transcranial photobiomodulation (tPBM) is the application of low levels of red or near-infrared (NIR) light to stimulate neural tissues. Here, we administer tPBM in the form of NIR light (810 nm wavelength) pulsed at 40 Hz to the default mode network (DMN), and examine its effects on human neural oscillations, in a randomized, sham-controlled, double-blinded trial. Using electroencephalography (EEG), we found that a single session of tPBM significantly increases the power of the higher oscillatory frequencies of alpha, beta and gamma and reduces the power of the slower frequencies of delta and theta in subjects in resting state. Furthermore, the analysis of network properties using inter-regional synchrony via weighted phase lag index (wPLI) and graph theory measures, indicate the effect of tPBM on the integration and segregation of brain networks. These changes were significantly different when compared to sham stimulation. Our preliminary findings demonstrate for the first time that tPBM can be used to non-invasively modulate neural oscillations, and encourage further confirmatory clinical investigations.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.