Acute Dietary Nitrate Supplementation Improves Flow Mediated Dilatation of the Superficial Femoral Artery in Healthy Older Males
Walker MA, Bailey TG, McIlvenna L, Allen JD, Green DJ, Askew CD
Nutrients · 50 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of the Sunshine Coast
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-04-26 · Nutrients · vol. 11 · issue 5 · p. 954
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 60 citations · more than 95% of similar papers · 4.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 108 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Cardiovascular Health and Disease Prevention · Cardiovascular and exercise physiology · Heart Rate Variability and Autonomic Control
- Keywords
- Medicine, Nitrate, Cardiology, Superficial femoral artery, Femoral artery, Internal medicine, Artery, Endocrinology, Biology
- MeSH
- femoral artery, humans, nitrates, blood pressure, vasodilation, dietary supplements, aged, middle aged, male
6 authors
From AU, US
- Meegan Anne WalkerUniversity of the Sunshine Coast
- Tom G. BaileyThe University of Queensland; University of the Sunshine Coast
- Luke C. McIlvennaVictoria University
- Jason David AllenUniversity of Virginia; Victoria University
- DANIEL JOHN GREENThe University of Western Australia; Government of Western Australia Department of Health
- Christopher David AskewUniversity of the Sunshine Coast; Sunshine Coast University Hospital
Abstract
Aging is often associated with reduced leg blood flow, increased arterial stiffness, and endothelial dysfunction, all of which are related to declining nitric oxide (NO) bioavailability. Flow mediated dilatation (FMD) and passive leg movement (PLM) hyperaemia are two techniques used to measure NO-dependent vascular function. We hypothesised that acute dietary nitrate (NO3-) supplementation would improve NO bioavailability, leg FMD, and PLM hyperaemia. Fifteen healthy older men (69 ± 4 years) attended two experiment sessions and consumed either 140 mL of concentrated beetroot juice (800 mg NO3-) or placebo (NO3--depleted beetroot juice) in a randomised, double blind, cross-over design study. Plasma nitrite (NO2-) and NO3-, blood pressure (BP), augmentation index (AIx75), pulse wave velocity (PWV), FMD of the superficial femoral artery, and PLM hyperaemia were measured immediately before and 2.5 h after consuming NO3- and placebo. Placebo had no effect but NO3- led to an 8.6-fold increase in plasma NO2-, which was accompanied by an increase in FMD (NO3-: +1.18 ± 0.94% vs. placebo: 0.23 ± 1.13%, p = 0.002), and a reduction in AIx75 (NO3-: -8.7 ± 11.6% vs. placebo: -4.6 ± 5.5%, p = 0.027). PLM hyperaemia, BP, and PWV were unchanged during both trials. This study showed that a dose of dietary NO3- improved NO bioavailability and enhanced endothelial function as measured by femoral artery FMD. These findings provide insight into the specific central and peripheral vascular responses to dietary NO3- supplementation in older adults.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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