A Prospective Study of Nut Consumption and Risk of Primary Hepatocellular Carcinoma in the U.S. Women and Men
Sui J, Yang W, Ma Y, Li TY, Simon TG, Meyerhardt JA, Liang G, Giovannucci EL, Chan AT, Zhang X
Cancer prevention research (Philadelphia, Pa.) · 19 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Nonprofit
- American Cancer Society
- Government
- National Institutes of Health
- Government
- National Cancer Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NCI NIH HHS
- Government
- NIH
- Nonprofit
- American Cancer Society Research Scholar Grant
- Government
- NIDDK NIH HHS
- Grants
- National Cancer Institute (U01 CA167552); National Cancer Institute (R03 CA176717); National Cancer Institute (P01 CA087969); National Cancer Institute (UM1 CA186107); National Cancer Institute (UM1-CA-167552); National Cancer Institute (K07 CA188126); American Cancer Society (RSG130476); National Institute of Diabetes and Digestive and Kidney Diseases (K24 [DK]098311); National Institutes of Health (K24 DK098311); National Institutes of Health (K07CA188126)
Based on 8 listed funder(s).
Publication
- Published
- 2019-04-30 · Cancer Prev Res (Phila) · vol. 12 · issue 6 · pp. 367–374
- Publisher
- American Association for Cancer Research
- Cited
- 23 citations · more than 81% of similar papers · 1.7× the field average
- References
- 57 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Nuts composition and effects · Horticultural and Viticultural Research · Peanut Plant Research Studies
- Keywords
- Hepatocellular carcinoma, Nut, Medicine, Consumption (sociology), Prospective cohort study, Environmental health, Primary prevention, Oncology, Internal medicine, Demography, Sociology, Disease
- MeSH
- humans, nuts, carcinoma, hepatocellular, liver neoplasms, prognosis, risk factors, case-control studies, follow-up studies, prospective studies, feeding behavior, adult, aged, middle aged, united states, female, male
10 authors
From US, CN
- Jing SuiBrigham and Women's Hospital; Southeast University
- Wanshui YangBrigham and Women's Hospital; Anhui Medical University
- Yanan MaBrigham and Women's Hospital; China Medical University
- Tricia Y. LiBrigham and Women's Hospital
- Tracey G. SimonMassachusetts General Hospital
- Jeffrey A. MeyerhardtDana-Farber Cancer Institute
Abstract
Although increasing evidence suggests a potential beneficial effect of nut consumption on various diseases, no epidemiologic study has yet examined the association between nut consumption and risk of hepatocellular carcinoma (HCC). We prospectively examined this association in 88,783 women from the Nurses' Health Study and 51,492 men from the Health Professionals Follow-up Study. Nut consumption was assessed every 4 years using validated food frequency questionnaires. Multivariable HRs and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards regression models after adjusting for HCC risk factors. After an average of 27.9 years of follow-up, we identified a total of 162 incident HCC cases. Higher total nut consumption was not significantly associated with HCC risk (the highest vs. lowest tertile intake, HR, 0.84; 95% CI, 0.56-1.26). For the same comparison, higher tree nut consumption was associated with a lower HCC risk (HR, 0.64; 95% CI, 0.43-0.95). We found nonsignificant inverse associations with consumption of walnuts, peanuts, and peanut butter. Overall, nut consumption was not strongly associated with HCC risk. There was a suggestive inverse association with tree nut consumption. Future studies should carefully consider hepatitis B or C virus infections and examine these associations in other racial/ethnic groups.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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