Photobiomodulation Therapy in Cancer Patients with Mucositis: A Clinical Evaluation
Pinheiro SL, Bonadiman AC, Borges Lemos ALDA, Annicchino BM, Segatti B, Pucca DS, Dutra PT, de Carvalho E Silva RM, Leal F
Photobiomodulation, photomedicine, and laser surgery · 31 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2019-02-20 · Photobiomodul Photomed Laser Surg · vol. 37 · issue 3 · pp. 142–150
- Publisher
- Mary Ann Liebert, Inc.
- Cited
- 48 citations · more than 90% of similar papers · 2.5× the field average
- References
- 30 works
- Access
- Paywalled
- Research areas
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Cancer Diagnosis and Treatment
- Keywords
- Mucositis, Medicine, Cancer, Cancer therapy, Intensive care medicine, Oncology, Dermatology, Internal medicine, Radiation therapy
- MeSH
- humans, neoplasms, stomatitis, curcumin, photosensitizing agents, treatment outcome, photochemotherapy, follow-up studies, adult, aged, aged, 80 and over, middle aged, female, male, low-level light therapy
9 authors
From BR
- Sérgio Luiz Pinheiro · correspondingPontifícia Universidade Católica de Campinas
- Ana Cláudia BonadimanPontifícia Universidade Católica de Campinas
- Ana Luiza dos Anjos Borges LemosPontifícia Universidade Católica de Campinas
- Bruna Maki AnnicchinoPontifícia Universidade Católica de Campinas
- Bruna SegattiPontifícia Universidade Católica de Campinas
- Daniel Sartorelli PuccaPontifícia Universidade Católica de Campinas
Abstract
Objective: To evaluate the use of photobiomodulation therapy (PBM-T) in patients undergoing chemotherapy and/or radiotherapy and affected by oral mucositis (OM). Background: Few clinical studies have evaluated PBM-T, particularly in combination with photodynamic therapy (PDT), for the treatment of OM. Methods: Thirty-one patients were divided by convenience into two groups. One received PBM-T (n = 17) alone, consisting of low-intensity laser (LIL) irradiation (wavelength 660 nm, continuous mode, spot energy 4 J, energy density 142 J/cm2, irradiation time 40 s per spot), once weekly for 4 weeks. The other (n = 14) received a combination of PBM-T and PDT, with curcumin as photosensitizer. Patients were instructed to rinse their mouth with 20 mL of curcumin solution for 5 min. The oral cavity was irradiated with a blue light-emitting diode (power 1200 mV, wavelength 468 nm) for 5 min. LIL was applied as in the PBM-T group. After treatment, OM severity was reassessed. The results were analyzed by the Wilcoxon and Mann-Whitney tests. Results: Both PBM-T alone and PBM-T+PDT yielded significant reductions in OM grade (p p = 0.0321). Conclusions: Within the parameters of this study, PBM-T+PDT was an effective method to accelerate the OM healing process.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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