Successful cholecalciferol desensitisation in a case of delayed hypersensitivity
Anantharajah A, Lamproglou A, Bridle S, Chen W, Tong W
Asia Pacific allergy · 3 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case report (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2019-04-01 · Asia Pac Allergy · vol. 9 · issue 2 · p. e14
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 4 citations · more than 53% of similar papers · 0.2× the field average
- References
- 5 works
- Access
- Free to read
- Research areas
- Drug-Induced Adverse Reactions · Urticaria and Related Conditions · Autoimmune Bullous Skin Diseases
- Keywords
- Medicine, Cholecalciferol, Provocation test, Culprit, Hypersensitivity reaction, Calcitriol, Differential diagnosis, Vitamin D and neurology, Drug, Desensitization (medicine), Internal medicine, Dermatology, Pharmacology, Pathology, Receptor
5 authors
From AU
- Anthea Anantharajah · correspondingAustralian National University; Canberra Hospital
- Anthony LamproglouSt Vincent's Hospital Sydney
- Sylvia BridleSt Vincent's Hospital Sydney
- Weiwen ChenGarvan Institute of Medical Research
- Winnie W.Y. TongSt Vincent's Hospital Sydney
Abstract
Hypersensitivity to cholecalciferol (vitamin D3) or its active metabolite, calcitriol, is an exceedingly rare clinical phenomenon, with only 2 previously reported cases of suspected immediate hypersensitivity. Diagnosis of delayed drug hypersensitivity reactions is inherently difficult due to the lack of any robust in vitro diagnostic assay, particularly in those patients for whom provocation testing confers an unacceptable risk. In these situations, diagnosis relies on reproducible clinical manifestations following administration of the culprit agent, resolution upon its withdrawal and exclusion of other potential differential diagnoses. Based on these criteria, we propose the first reported case of delayed hypersensitivity to cholecalciferol successfully managed with a desensitisation protocol to pure cholecalciferol.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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