Serum 25-hydroxyvitamin D is associated with obesity and metabolic parameters in US children
Fu Z, Xu C, Shu Y, Xie Z, Lu C, Mo X
Public health nutrition · 36 citations
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Key Research and Development Program of China
- Grants
- National Key Research and Development Program of China (2016YFC1101001); National Key Research and Development Program of China (2017YFC1308105)
Based on 1 listed funder(s).
Publication
- Published
- 2019-05-23 · Public Health Nutr · vol. 23 · issue 7 · pp. 1214–1222
- Publisher
- Cambridge University Press
- Cited
- 51 citations · more than 93% of similar papers · 3.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 58 works
- Access
- Free to read
- Research areas
- Vitamin D Research Studies · Nutritional Studies and Diet · Sexual Differentiation and Disorders
- Keywords
- Medicine, Insulin resistance, Obesity, Vitamin D and neurology, Internal medicine, vitamin D deficiency, Odds ratio, Metabolic syndrome, Endocrinology, Population, National Health and Nutrition Examination Survey, Odds, Logistic regression, Environmental health
- MeSH
- humans, insulin resistance, vitamin d deficiency, blood glucose, lipids, vitamin d, body mass index, nutrition surveys, risk factors, cross-sectional studies, adolescent, child, united states, female, male, adiposity, cholesterol, hdl, pediatric obesity, metabolic syndrome
6 authors
From CN
- Zhi FuHuaian First People’s Hospital; Second Affiliated Hospital of Nanjing Medical University; Nanjing Medical University
- Cheng Yu XuSecond Affiliated Hospital of Nanjing Medical University
- Yaqin ShuSecond Affiliated Hospital of Nanjing Medical University
- Zongyun XieSecond Affiliated Hospital of Nanjing Medical University
- Changgui LuSecond Affiliated Hospital of Nanjing Medical University
- Xuming Mo · correspondingSecond Affiliated Hospital of Nanjing Medical University
Abstract
Objective
To explore the relationships of serum 25-hydroxyvitamin D (25(OH)D) with obesity and metabolic parameters in US children.
Design
Cross-sectional analysis. We evaluated the associations between serum 25(OH)D and multiple measurements of adiposity, serum lipid concentrations, fasting glucose and insulin resistance in children aged 6-18 years with adjustments for multiple covariates.
Setting
The National Health and Nutrition Examination Survey, 2001-2006.
Participants
A nationally representative sample of 6311 children and adolescents aged 6-18 years.
Results
Among US children and adolescents, the prevalence of vitamin D deficiency has been especially high in older children, girls and the non-Hispanic Black population. Higher odds of obesity were found at a 25(OH)D concentration of 50 nmol/l under both criteria for obesity in children (OR = 3·27, Ptrend ≤ 0.001). Moreover, increased odds of having abnormal HDL-cholesterol (OR = 1·71, Ptrend ≤ 0.001) and impaired insulin resistance (OR = 4·15, Ptrend ≤ 0·001) were found for children deficient in 25(OH)D compared with those with normal 25(OH)D concentrations. When the children and adolescents were stratified by gender, we found stronger associations between serum 25(OH)D concentration and both HDL-cholesterol and insulin resistance in girls. No association of 25(OH)D with any other metabolic parameter was found.
Conclusions
Our results suggest a potential harmful association between low serum 25(OH)D concentration and the risk of obesity among children. However, the underlying mechanisms require further investigation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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