Funded in part by Novo Nordisk, Novo Nordisk Fonden
A Joint Modeling Approach for Childhood Meat, Fish and Egg Consumption and the Risk of Advanced Islet Autoimmunity
Syrjälä E, Nevalainen J, Peltonen J, Peltonen J, Takkinen HM, Hakola L, Åkerlund M, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM
Scientific reports · 20 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Nonprofit
- Juvenile Diabetes Research Foundation International
- Government
- European Commission
- Nonprofit
- European Foundation for the Study of Diabetes
- Government
- Academy of Finland
- Nonprofit
- Juho Vainion Säätiö
- Company
- Novo Nordisk
- Nonprofit
- Diabetesliitto
- Company
- Novo Nordisk Fonden
- Unclassified
- Tays
- University or hospital
- Turun Yliopistollinen Keskussairaala
- Nonprofit
- Diabetestutkimussäätiö
- Government
- Fonds Spéciaux de Recherche
- Grants
- Academy of Finland (79 686); Academy of Finland (20122017); Academy of Finland (126813); Academy of Finland (114666); Academy of Finland (308 066); Juvenile Diabetes Research Foundation International (4‐1998‐274); Juvenile Diabetes Research Foundation International (4‐1999‐731); European Commission (250114); Academy of Finland (63 672); European Commission (276475); Juvenile Diabetes Research Foundation International (68292); Juvenile Diabetes Research Foundation International (4-1998-274, 4-1999-731, 4-2001-435); Academy of Finland (201 988); Academy of Finland (68292); Academy of Finland (129 492); European Commission (BMH4‐CT98‐3314); Academy of Finland (80 846); Juho Vainion Säätiö (9H092); Academy of Finland (210 632); Tays (9S074); Juho Vainion Säätiö (9M036); Diabetestutkimussäätiö (BMH4-CT98-3314); Academy of Finland (276475); European Commission (4-1998-274); Juho Vainion Säätiö (9P057); Academy of Finland (250114); Tays (9P057); Juho Vainion Säätiö (9G087); Academy of Finland (139391); Juho Vainion Säätiö (9R055); Juho Vainion Säätiö (9K149); Tays (9R055); Juho Vainion Säätiö (9F089); Academy of Finland (Decision No. 250114); Juho Vainion Säätiö (9S074); European Commission (4-1999-731); Diabetestutkimussäätiö (250114); Academy of Finland (79 685); Juho Vainion Säätiö (9J147); Juho Vainion Säätiö (9N086); European Commission (68292); Juho Vainion Säätiö (9L042); Juvenile Diabetes Research Foundation International (4‐2001‐435); European Commission (4-2001-435); Juho Vainion Säätiö (9E082); Juho Vainion Säätiö (9L117); Academy of Finland (Physiology Research 2012-2017)
Based on 12 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-05-23 · Sci Rep · vol. 9 · issue 1 · p. 7760
- Publisher
- Nature Portfolio
- Cited
- 22 citations · more than 85% of similar papers · 1.8× the field average
- References
- 53 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Diabetes and associated disorders · Diet, Metabolism, and Disease · Pancreatic function and diabetes
- Keywords
- Hazard ratio, Proportional hazards model, Confounding, Medicine, Prospective cohort study, Type 1 diabetes, Population, Cohort, Diabetes mellitus, Cohort study, Environmental health, Internal medicine, Confidence interval, Endocrinology
- MeSH
- islets of langerhans, animals, fishes, humans, diabetes mellitus, type 1, food hypersensitivity, genetic predisposition to disease, autoantibodies, diet therapy, diet, models, statistical, proportional hazards models, risk factors, cohort studies, prospective studies, autoimmunity, eggs, meat, adolescent, child, child, preschool, infant, infant, newborn, finland, female, male, hla-dq beta-chains
11 authors
From FI
- Essi Syrjälä · correspondingTampere University; Tampere University
- Jaakko NevalainenTampere University
- Jaakko PeltonenTampere University
- Hanna‐Mari TakkinenTampere University; Finnish Institute for Health and Welfare
- Leena HakolaTampere University
- Iris ErlundTampere University; Finnish Institute for Health and Welfare
Abstract
Several dietary factors have been suspected to play a role in the development of advanced islet autoimmunity (IA) and/or type 1 diabetes (T1D), but the evidence is fragmentary. A prospective population-based cohort of 6081 Finnish newborn infants with HLA-DQB1-conferred susceptibility to T1D was followed up to 15 years of age. Diabetes-associated autoantibodies and diet were assessed at 3- to 12-month intervals. We aimed to study the association between consumption of selected foods and the development of advanced IA longitudinally with Cox regression models (CRM), basic joint models (JM) and joint latent class mixed models (JLCMM). The associations of these foods to T1D risk were also studied to investigate consistency between alternative endpoints. The JM showed a marginal association between meat consumption and advanced IA: the hazard ratio adjusted for selected confounding factors was 1.06 (95% CI: 1.00, 1.12). The JLCMM identified two classes in the consumption trajectories of fish and a marginal protective association for high consumers compared to low consumers: the adjusted hazard ratio was 0.68 (0.44, 1.05). Similar findings were obtained for T1D risk with adjusted hazard ratios of 1.13 (1.02, 1.24) for meat and 0.45 (0.23, 0.86) for fish consumption. Estimates from the CRMs were closer to unity and CIs were narrower compared to the JMs. Findings indicate that intake of meat might be directly and fish inversely associated with the development of advanced IA and T1D, and that disease hazards in longitudinal nutritional epidemiology are more appropriately modeled by joint models than with naive approaches.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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