Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant
Rosado C, Tokunaga VK, Sauce R, de Oliveira CA, Sarruf FD, Parise-Filho R, Maurício E, de Almeida TS, Velasco MVR, Baby AR
Frontiers in physiology · 25 citations
Review labels
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How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Government
- Fundação para a Ciência e a Tecnologia
- Authors
- At least one author declares a financial tie to industry
- Grants
- Fundação para a Ciência e a Tecnologia (UID/DTP/04567/2016); Fundação de Amparo à Pesquisa do Estado de São Paulo (13/08535-0); Conselho Nacional de Desenvolvimento Científico e Tecnológico (Code 001); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior ((Code 001)); Fundação de Amparo à Pesquisa do Estado de São Paulo (13/18689-5); Fundação de Amparo à Pesquisa do Estado de São Paulo (12/04435-9); Fundação de Amparo à Pesquisa do Estado de São Paulo (Code 001)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-05-03 · Front Physiol · vol. 10 · p. 519
- Publisher
- Frontiers Media
- Cited
- 55 citations · more than 94% of similar papers · 4.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 54 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Skin Protection and Aging · Bee Products Chemical Analysis · Coffee research and impacts
- Keywords
- Caffeine, In vivo, Sun protection factor, Adjuvant, Erythema, Sunscreening Agents, Pharmacology, Stratum corneum, Skin cancer, Context (archaeology), Transepidermal water loss, Chemistry, Dermatology, Medicine, Cancer, Immunology, Pathology, Biology, Internal medicine
10 authors
From PT, BR
- Catarina RosadoUniversidade Lusófona
- Viviane Kaori TokunagaUniversidade de São Paulo
- Rafael SauceUniversidade de São Paulo
- Camila Areias de OliveiraUniversidade de São Paulo
- Fernanda Daud SarrufInstitute of Integrated Clinical Research (Brazil)
- Roberto Parise‐FilhoUniversidade de São Paulo
Abstract
The excessive exposure to ultraviolet (UV) radiation is the main cause of skin cancer, the most commonly diagnosed cancer in the world. In this context, the development of innovative and more effective sunscreens, with bioactive compounds like caffeine, displaying antioxidant and anticancer potential, is required. This research work assessed in vitro and in vivo the efficacy and safety of topical sunscreen formulations containing caffeine as an adjuvant of the UV filters. Sunscreens were prepared with 2.5% w/w caffeine or in the absence of this compound. In order to evaluate the safety of these formulations, stratum corneum hydration, skin barrier and colorimetry were assessed in vivo in healthy subjects before and after skin treatment with the samples. The efficacy of the sunscreens was assessed in vitro, using PMMA plates and a spectrophotometer equipped with an integrating sphere; and in vivo by the determination of the sun protection factor (SPF). None of the formulations caused erythema or impaired the skin barrier function. The in vitro functional characterization showed higher SPF values for the caffeine formulation. The in vivo studies also confirmed the higher SPF value of the formulation combining caffeine with the filters, compared to the caffeine-free sample. This improvement contributed to an increase of, approximately, 25% in the in vivo anti-UVB protection. In conclusion, caffeine was well tolerated by the skin and increased the photoprotective activity, being a new alternative adjuvant in sunscreens formulation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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