Ultra-processed Food Consumption and Incident Frailty: A Prospective Cohort Study of Older Adults
Sandoval-Insausti H, Blanco-Rojo R, Graciani A, López-García E, Moreno-Franco B, Laclaustra M, Donat-Vargas C, Ordovás JM, Rodríguez-Artalejo F, Guallar-Castillón P
The journals of gerontology. Series A, Biological sciences and medical sciences · 64 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Unclassified
- Ageing Trajectories of Health: Longitudinal Opportunities and Synergies
- Unclassified
- SALAMANDER
- Government
- State Secretary of R+D and FEDER/FSE
Based on 3 listed funder(s).
Publication
- Published
- 2019-05-27 · J Gerontol A Biol Sci Med Sci · vol. 75 · issue 6 · pp. 1126–1133
- Publisher
- Oxford University Press
- Cited
- 94 citations · more than 99% of similar papers · 9.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 46 works
- Access
- Paywalled
- Research areas
- Consumer Attitudes and Food Labeling · Nutrition and Health in Aging · Nutritional Studies and Diet
- Keywords
- Medicine, Quartile, Prospective cohort study, Confounding, Cohort, Environmental health, Logistic regression, Cohort study, Food science, Gerontology, Confidence interval, Internal medicine
- MeSH
- humans, diet, diet surveys, incidence, prospective studies, feeding behavior, age factors, food handling, food, aged, aged, 80 and over, frail elderly, middle aged, spain, female, male, frailty
10 authors
From US, ES, SE
- Helena Sandoval‐InsaustiHarvard University; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Universidad Autónoma de Madrid
- Ruth Blanco-RojoMadrid Institute for Advanced Studies; IMDEA Food; Universidad Autónoma de Madrid
- Auxiliadora GracianiCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Universidad Autónoma de Madrid
- Esther López‐GarcíaMadrid Institute for Advanced Studies; IMDEA Food; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Universidad Autónoma de Madrid
- Belén Moreno‐FrancoUniversidad de Zaragoza; Centro de Investigación en Red en Enfermedades Cardiovasculares; Hospital Universitario Miguel Servet; Instituto de Investigación Sanitaria Aragón
- Martín LaclaustraFundacion Agencia Aragonesa para la Investigacion y el Desarrollo; Centro de Investigación en Red en Enfermedades Cardiovasculares; Hospital Universitario Miguel Servet; Instituto de Investigación Sanitaria Aragón
Abstract
Background
Ultra-processed food intake has been associated with chronic conditions and mortality. The aim of this study was to assess the relationship between ultra-processed food intake and incident frailty in community-dwelling older adults.
Methods
Prospective cohort study with 1,822 individuals aged at least 60 years who were recruited during 2008-2010 in Spain. At baseline, food consumption was obtained using a validated computerized face-to-face dietary history. Ultra-processed foods were identified according to the nature and extent of their industrial processing (NOVA classification). In 2012, incident frailty was ascertained based on Fried's criteria. Statistical analyses were performed with logistic regression and adjusted for the main potential confounders.
Results
After a mean follow-up of 3.5 years, 132 cases of frailty were identified. The fully adjusted risks of frailty across increasing quartiles of the percentage of total energy intake from ultra-processed foods were the following: 0.04 (0.02-0.05), 0.05 (0.03-0.07), 0.09 (0.07-0.12), and 0.11 (0.08-0.14). Results were similar when food consumption was expressed as gram per day/body weight. Regarding ultra-processed food groups, the highest versus the lowest tertiles of consumption of yogurts and fermented milks, cakes and pastries, as well as nonalcoholic beverages (instant coffee and cocoa, packaged juices, and other nonalcoholic drinks, excluding soft drinks) were also significantly related to incident frailty.
Conclusions
Consumption of ultra-processed foods is strongly associated with frailty risk in older adults. Substituting unprocessed or minimally processed foods for ultra-processed foods would play an important role in the prevention of age-related frailty.
Trial registration
NCT02804672.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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