Differential Anti-Adipogenic Effects of Eicosapentaenoic and Docosahexaenoic Acids in Obesity
Zhuang P, Lu Y, Shou Q, Mao L, He L, Wang J, Chen J, Zhang Y, Jiao J
Molecular nutrition & food research · 32 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Grants
- National Natural Science Foundation of China (81300309); National Natural Science Foundation of China (81773419)
Based on 1 listed funder(s).
Publication
- Published
- 2019-05-29 · Mol Nutr Food Res · vol. 63 · issue 14 · p. e1801135
- Publisher
- Wiley
- Cited
- 46 citations · more than 95% of similar papers · 4.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 63 works
- Access
- Paywalled
- Research areas
- Fatty Acid Research and Health · Adipose Tissue and Metabolism · Eicosanoids and Hypertension Pharmacology
- Keywords
- Eicosapentaenoic acid, Docosahexaenoic acid, Internal medicine, Endocrinology, Adipogenesis, Adipose tissue, White adipose tissue, Overweight, Chemistry, Population, Obesity, Medicine, Fatty acid, Food science, Polyunsaturated fatty acid, Biochemistry
- MeSH
- 3t3-l1 cells, animals, mice, inbred c57bl, humans, mice, obesity, docosahexaenoic acids, eicosapentaenoic acid, anti-obesity agents, nutrition surveys, dietary supplements, middle aged, united states, female, male, adipogenesis, body fat distribution, adipose tissue, white, diet, high-fat
9 authors
From CN
- Pan ZhuangMinistry of Agriculture and Rural Affairs; Zhejiang University
- Yanhua LuHangzhou Normal University
- Qiyang ShouZhejiang Chinese Medical University
- Lei MaoZhejiang University
- Lilin HeMinistry of Agriculture and Rural Affairs; Zhejiang University
- Jun WangMinistry of Agriculture and Rural Affairs; Zhejiang University
Abstract
Scope
To assess the associations of plasma eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) with body fat in a population-based sample and explore the mechanism of action based on browning of white adipose tissue (WAT) in high-fat-diet-induced obese (DIO) mice and 3T3-L1 adipocytes.
Methods and results
Plasma EPA and DHA of 1719 adults in the National Health and Nutrition Examination Survey (2003-2004) are determined by gas chromatography mass spectrometry, while total body fat is measured by dual-energy X-ray absorptiometry. DIO mice are fed a high-fat diet supplemented with EPA or DHA (1% wt/wt) for 15 weeks and 3T3-L1 preadipocytes are treated with EPA or DHA during differentiation. Plasma DHA but not EPA is associated with lower body fat mass (ptrend trend = 0.02). DHA supplementation reduces inguinal WAT and exhibits a more pronounced thermogenic effect than EPA in DIO mice. In vitro, the browning process is induced after 2-day and 6-day treatment with DHA and EPA, respectively.
Conclusion
Plasma DHA but not EPA is inversely associated with body fat mass. The more potent anti-adipogenic effect of DHA than EPA may involve a better capability of inducing browning of WAT for DHA.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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