Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans
Jamshed H, Beyl RA, Della Manna DL, Yang ES, Ravussin E, Peterson CM
Nutrients · 514 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Obesity Society
- University or hospital
- University of Alabama at Birmingham
- University or hospital
- University of Alabama
- University or hospital
- Louisiana Clinical and Translational Science Center
- Government
- National Institutes of Health
- University or hospital
- Nutrition Obesity Research Center, University of North Carolina
- Government
- National Institute of General Medical Sciences
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Center for Advancing Translational Sciences
- Government
- NIDDK NIH HHS
- Government
- NIGMS NIH HHS
- Government
- NCATS NIH HHS
- Nonprofit
- The Obesity Society
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079626); National Institute of General Medical Sciences (P30 DK072476); National Institute of General Medical Sciences (U54‐ GM104940); Nutrition Obesity Research Center, University of North Carolina (#P30DK072476); Nutrition Obesity Research Center, University of North Carolina (DK072476); Louisiana Clinical and Translational Science Center (U54GM104940); National Institute of General Medical Sciences (GM104940); National Center for Advancing Translational Sciences (KL2 TR001419); Louisiana Clinical and Translational Science Center (GM104940); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-072476); Nutrition Obesity Research Center, University of North Carolina (U54 GM104940); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK-056336)
Based on 13 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-05-30 · Nutrients · vol. 11 · issue 6 · p. 1234
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 671 citations · more than 100% of similar papers · 33.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 69 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Diet and metabolism studies
- Keywords
- Circadian rhythm, Endocrinology, Morning, Internal medicine, Evening, CLOCK, Circadian clock, Biology, Hormone, Autophagy, Gene expression, Carbohydrate metabolism, TXNIP, Medicine, Gene, Genetics, Oxidative stress, Apoptosis
- MeSH
- humans, blood glucose, fasting, cross-over studies, gene expression regulation, circadian rhythm, aging, eating, time factors, autophagy, meals, biomarkers
6 authors
From US
- Humaira JamshedUniversity of Alabama at Birmingham
- Robbie A. BeylPennington Biomedical Research Center
- Deborah Della MannaUniversity of Alabama at Birmingham
- Eddy Shih-Hsin YangUniversity of Alabama at Birmingham
- Éric RavussinPennington Biomedical Research Center
- Courtney M. Peterson · correspondingUniversity of Alabama at Birmingham
Abstract
Time-restricted feeding (TRF) is a form of intermittent fasting that involves having a longer daily fasting period. Preliminary studies report that TRF improves cardiometabolic health in rodents and humans. Here, we performed the first study to determine how TRF affects gene expression, circulating hormones, and diurnal patterns in cardiometabolic risk factors in humans. Eleven overweight adults participated in a 4-day randomized crossover study where they ate between 8 am and 2 pm (early TRF (eTRF)) and between 8 am and 8 pm (control schedule). Participants underwent continuous glucose monitoring, and blood was drawn to assess cardiometabolic risk factors, hormones, and gene expression in whole blood cells. Relative to the control schedule, eTRF decreased mean 24-hour glucose levels by 4 ± 1 mg/dl (p = 0.0003) and glycemic excursions by 12 ± 3 mg/dl (p = 0.001). In the morning before breakfast, eTRF increased ketones, cholesterol, and the expression of the stress response and aging gene SIRT1 and the autophagy gene LC3A (all p p = 0.10) and also increased the expression of MTOR (p = 0.007), a major nutrient-sensing protein that regulates cell growth. eTRF also altered the diurnal patterns in cortisol and the expression of several circadian clock genes (p < 0.05). eTRF improves 24-hour glucose levels, alters lipid metabolism and circadian clock gene expression, and may also increase autophagy and have anti-aging effects in humans.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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