Funded in part by Ferring Pharmaceuticals
Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals
Kolar MJ, Konduri S, Chang T, Wang H, McNerlin C, Ohlsson L, Härröd M, Siegel D, Saghatelian A
The Journal of biological chemistry · 97 citations
Review labels
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How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Industry funded
- Government
- National Institutes of Health
- Government
- National Cancer Institute
- Government
- National Institute of General Medical Sciences
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIH HHS
- Government
- NIGMS NIH HHS
- Company
- Ferring Pharmaceuticals
- Government
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK))
- Government
- NIDDK NIH HHS
- Government
- HHS | NIH | National Cancer Institute (NCI))
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (CA014195); National Institute of Diabetes and Digestive and Kidney Diseases (RC2 DK114785); National Institutes of Health (1s10od021815-01); National Institute of General Medical Sciences (T32-GM007198); National Institute of Diabetes and Digestive and Kidney Diseases (DK106210); National Institute of Diabetes and Digestive and Kidney Diseases (F30 DK112604); National Institute of Diabetes and Digestive and Kidney Diseases (CA014195); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK106210); National Institute of Diabetes and Digestive and Kidney Diseases (F31 DK112604); National Institute of Diabetes and Digestive and Kidney Diseases (R56 DK110150); National Cancer Institute (P30 CA-014195); National Institute of Diabetes and Digestive and Kidney Diseases (R56 DK110150-01A1); National Institutes of Health (CA014195); National Institutes of Health (R01 DK106210)
Based on 11 listed funder(s).
Publication
- Published
- 2019-05-31 · J Biol Chem · vol. 294 · issue 27 · pp. 10698–10707
- Publisher
- Elsevier BV
- Cited
- 150 citations · more than 98% of similar papers · 7.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 43 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Fatty Acid Research and Health · Cholesterol and Lipid Metabolism · Eicosanoids and Hypertension Pharmacology
- Keywords
- Linoleic acid, Lipopolysaccharide, Biochemistry, Adipose tissue, Chemistry, Secretion, Fatty acid, Biological activity, Biology, In vitro, Immunology
- MeSH
- adipose tissue, macrophages, animals, humans, mice, esters, lipopolysaccharides, linoleic acids, plant oils, anti-inflammatory agents, cytokines, chromatography, high pressure liquid, cell proliferation, stereoisomerism, mass spectrometry, avena, raw 264.7 cells
9 authors
From US, SE, CH
- Matthew J. KolarSalk Institute for Biological Studies
- Srihari KonduriUniversity of California San Diego
- Tina ChangSalk Institute for Biological Studies
- Huijing WangUniversity of California San Diego
- Clare McNerlinUniversity of California San Diego
- Lena OhlssonLund University
Abstract
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a recently discovered class of biologically active lipids. Here we identify the linoleic acid ester of 13-hydroxy linoleic acid (13-LAHLA) as an anti-inflammatory lipid. An oat oil fraction and FAHFA-enriched extract from this fraction showed anti-inflammatory activity in a lipopolysaccharide-induced cytokine secretion assay. Structural studies identified three LAHLA isomers (15-, 13-, and 9-LAHLA) as being the most abundant FAHFAs in the oat oil fraction. Of these LAHLAs, 13-LAHLA is the most abundant LAHLA isomer in human serum after ingestion of liposomes made of fractionated oat oil, and it is also the most abundant endogenous LAHLA in mouse and human adipose tissue. As a result, we chemically synthesized 13-LAHLA for biological assays. 13-LAHLA suppresses lipopolysaccharide-stimulated secretion of cytokines and expression of pro-inflammatory genes. These studies identify LAHLAs as an evolutionarily conserved lipid with anti-inflammatory activity in mammalian cells.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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