Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial
Zhang Z, Garzotto M, Davis EW, Mori M, Stoller WA, Farris PE, Wong CP, Beaver LM, Thomas GV, Williams DE, Dashwood RH, Hendrix DA, Ho E, Shannon J
Nutrition and cancer · 66 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- University or hospital
- Oregon Agricultural Experimental Station, Hatch Funds
- Government
- NCI NIH HHS
- Government
- National Institute of Health
- Unclassified
- Clinical Trial Registration: clinicaltrials.gov identifier
- Grants
- National Cancer Institute (P01 CA090890)
Based on 5 listed funder(s).
Publication
- Published
- 2019-06-01 · Nutr Cancer · vol. 72 · issue 1 · pp. 74–87
- Publisher
- Routledge
- Cited
- 83 citations · more than 88% of similar papers · 2.1× the field average
- References
- 48 works
- Access
- Open access (repository copy)
- Research areas
- Genomics, phytochemicals, and oxidative stress · Reproductive System and Pregnancy
- Keywords
- Prostate cancer, Sulforaphane, Prostate, Medicine, Internal medicine, Prostate biopsy, Cruciferous vegetables, Cancer, Oncology, Cancer research
- MeSH
- prostate, humans, brassica, prostatic neoplasms, isothiocyanates, sulfoxides, histone deacetylases, racemases and epimerases, ki-67 antigen, anticarcinogenic agents, biopsy, chemoprevention, double-blind method, biological availability, aged, middle aged, male, cyclin-dependent kinase inhibitor p21, biomarkers, tumor, vegetable products
14 authors
From US
- Zhenzhen ZhangOregon Health & Science University
- Mark G. GarzottoOregon Health & Science University; Portland VA Medical Center
- Edward W. DavisOregon State University
- Motomi MoriOregon Health & Science University
- Wesley A. StollerOregon Health & Science University
- Paige E. FarrisOregon Health & Science University
Abstract
Previous studies suggest compounds such as sulforaphane (SFN) derived from cruciferous vegetables may prevent prostate cancer development and progression. This study evaluated the effect of broccoli sprout extract (BSE) supplementation on blood histone deacetylase (HDAC) activity, prostate RNA gene expression, and tissue biomarkers (histone H3 lysine 18 acetylation (H3K18ac), HDAC3, HDAC6, Ki67, and p21). A total of 98 men scheduled for prostate biopsy were allocated into either BSE (200 µmol daily) or a placebo in our double-blind, randomized controlled trial. We used nonparametric tests to evaluate the differences of blood HDAC activity and prostate tissue immunohistochemistry biomarkers between treatment groups. Further, we performed RNA-Seq analysis on the prostate biopsies and identified 40 differentially expressed genes correlated with BSE treatment, including downregulation of two genes previously implicated in prostate cancer development, AMACR and ARLNC1. Although urine and plasma SFN isothiocyanates and individual SFN metabolites were statistically higher in the treatment group, our results did not show a significant difference in HDAC activity or prostate tissue biomarkers. This study indicates BSE supplementation correlates with changes in gene expression but not with several other prostate cancer biomarkers. More research is required to fully understand the chemopreventive effects of BSE supplementation on prostate cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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