Association between nut consumption and non-alcoholic fatty liver disease in adults
Zhang S, Fu J, Zhang Q, Liu L, Meng G, Yao Z, Wu H, Bao X, Gu Y, Lu M, Sun S, Wang X, Zhou M, Jia Q, Song K, Xiang H, Wu Y, Niu K
Liver international : official journal of the International Association for the Study of the Liver · 44 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Grants
- National Natural Science Foundation of China (81,673,166); National Natural Science Foundation of China (81872611); National Natural Science Foundation of China (91,746,205)
Based on 1 listed funder(s).
Publication
- Published
- 2019-06-04 · Liver Int · vol. 39 · issue 9 · pp. 1732–1741
- Publisher
- Wiley
- Cited
- 53 citations · more than 95% of similar papers · 4.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 46 works
- Access
- Paywalled
- Research areas
- Nuts composition and effects · Oral Health Pathology and Treatment · Peanut Plant Research Studies
- Keywords
- Medicine, Fatty liver, Odds ratio, Internal medicine, Metabolic syndrome, Confidence interval, Population, Nut, Refined grains, Insulin resistance, Prospective cohort study, Confounding, Disease, Gastroenterology, Obesity, Environmental health, Food science, Biology
- MeSH
- humans, nuts, diet, logistic models, odds ratio, prospective studies, cross-sectional studies, life style, energy intake, adult, china, female, male, non-alcoholic fatty liver disease
18 authors
From CN
- Shunming ZhangTianjin Medical University
- Jingzhu FuTianjin Medical University
- Qing ZhangTianjin Medical University General Hospital
- Li LiuTianjin Medical University General Hospital
- Ge MengTianjin Medical University
- Zhanxin YaoTianjin Medical University
Abstract
Background & aims
Increased nut consumption has been associated with reduced inflammation, insulin resistance, and oxidative stress. Although these factors are closely involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), few studies have focused on the association between nut consumption and NAFLD in the general population. We aimed to investigate the association of nut consumption and NAFLD in an adult population.
Methods
A total of 23 915 participants from Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study were included in this study. Information on dietary intake was collected using a validated food frequency questionnaire. Abdominal ultrasonography was done to diagnose NAFLD. Multivariable logistic regression was used to assess the association of nut consumption with NAFLD.
Results
After adjusting for sociodemographic, medical, dietary, and lifestyle variables, the odds ratios (95% confidence interval) for NAFLD across categories of nut consumption were 1.00 (reference) for <1 time/week, 0.91 (0.82, 1.02) for 1 time/week, 0.88 (0.76, 1.02) for 2-3 times/week, and 0.80 (0.69, 0.92) for ≥4 times/week (P for trend < 0.01). These associations were attenuated but remained significant after further adjustment for blood lipids, glucose, and inflammation markers.
Conclusions
Higher nut consumption was significantly associated with lower prevalence of NAFLD. Further prospective studies and randomized trials are required to ascertain the causal association between nut consumption and NAFLD.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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