Cold-pressed Canola Oil Reduces Hepatic Steatosis by Modulating Oxidative Stress and Lipid Metabolism in KM Mice Compared with Refined Bleached Deodorized Canola Oil
Zhou YJ, Chang YN, You JQ, Li SZ, Zhuang W, Cao CJ
Journal of food science · 6 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Qinghai Science and Technology Department Grant
Based on 1 listed funder(s).
Publication
- Published
- 2019-06-10 · J Food Sci · vol. 84 · issue 7 · pp. 1900–1908
- Publisher
- Wiley
- Cited
- 15 citations · more than 78% of similar papers · 1.4× the field average
- References
- 48 works
- Access
- Paywalled
- Research areas
- Fatty Acid Research and Health · Cholesterol and Lipid Metabolism · Diet and metabolism studies
- Keywords
- Canola, Steatosis, Lipid metabolism, Chemistry, Fatty acid synthase, Oxidative stress, Hyperlipidemia, Biochemistry, Sterol, Food science, Cholesterol, Endocrinology, Internal medicine, Biology, Medicine, Diabetes mellitus
- MeSH
- liver, animals, humans, mice, fatty liver, insulin resistance, cholesterol, acetyl-coa carboxylase, fatty acids, triglycerides, phospholipids, ppar alpha, oxidative stress, male, lipogenesis, lipid metabolism, sterol regulatory element binding protein 1, fatty acid synthases, rapeseed oil
6 authors
From CN
- Yingjun ZhouEast China University of Science and Technology
- Yaning Chang · correspondingEast China University of Science and Technology
- Jiaqi YouEast China University of Science and Technology
- Sui‐Zi LiEast China University of Science and Technology
- Wei ZhuangEast China University of Science and Technology
- Cheng‐Jia CaoEast China University of Science and Technology
Abstract
The quality of canola oil is affected by different extraction methods. The effect of cold-pressed canola oil (CPCO) diet and traditional refined bleached deodorized canola oil (RBDCO) diet on lipid accumulation and hepatic steatosis in mice were investigated. The body weight, peroxisome proliferator-activated receptor-α concentration, serum lipid profile, insulin sensitivity, and oxidative stress were increased in mice fed with CPCO diet, which had higher unsaturated fatty acid, tocopherols, phytosterols, and phospholipids but lower saturated fatty acid than RBDCO, after 12 weeks,. Moreover, CPCO significantly increased tocopherols and phytosterols content in liver and reduced liver cholesterol contents and lipid vacuoles accumulation than RBDCO. Also, serum proinflammatory cytokines, 3-hydroxy-3-methylglutary coenzyme A reductase expression level, lipogenic enzymes, and transcriptional factors such as sterol regulatory element-binding proteins 1c, acetyl-CoA carboxylase, and fatty acid synthase in the liver were also markedly downregulated from CPCO diet mice. Overall, CPCO can reduce lipid accumulation and hepatic steatosis by regulating oxidative stress and lipid metabolism in Kun Ming mice compared with RBDCO. PRACTICAL APPLICATION: The results suggested that more bioactive components were contained in cold-pressed canola oil (CPCO) rather than refined bleached deodorized canola oil (RBDCO). CPCO could lower the risk of obesity and hyperlipidemia, reduce lipid accumulation, and prevent hepatic steatosis. It could be considered as a kind of better edible oil than RBDCO.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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