Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption
Villanueva JE, Livelo C, Trujillo AS, Chandran S, Woodworth B, Andrade L, Le HD, Manor U, Panda S, Melkani GC
Nature communications · 130 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Health and Human Services
- University or hospital
- San Diego State University
- Nonprofit
- Waitt Foundation
- Government
- National Institutes of Health
- Government
- Medical Research Council
- Government
- National Institute on Aging
- Government
- National Cancer Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Institute of Neurological Disorders and Stroke
- Government
- NCI NIH HHS
- Government
- NIDDK NIH HHS
- Government
- U.S. Department of Health & Human Services | NIH | National Institute on Aging
- Government
- NIA NIH HHS
- Government
- NINDS NIH HHS
- Grants
- National Cancer Institute (CA014195); National Institute on Aging (R01 AG049494); National Institute on Aging (R56 AG049494); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK115214); National Institute of Neurological Disorders and Stroke (P30 NS072031); National Institute of Neurological Disorders and Stroke (NS072031); National Cancer Institute (P30 CA-014195); U.S. Department of Health and Human Services (AG049494); Waitt Foundation (CA014195); National Institutes of Health (2r56ag049494-06a1); National Institute on Aging (AG049494); Medical Research Council (MR/L023784/1); National Institutes of Health (CA014195); National Institutes of Health (NS072031); National Institutes of Health (DK115214); National Institutes of Health (AG049494)
Based on 14 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-06-20 · Nat Commun · vol. 10 · issue 1 · p. 2700
- Publisher
- Nature Portfolio
- Cited
- 160 citations · more than 98% of similar papers · 8.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 75 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Genetics, Aging, and Longevity in Model Organisms
- Keywords
- Insulin resistance, Circadian rhythm, Skeletal muscle, Endocrinology, Biology, Internal medicine, Obesity, Medicine
- MeSH
- sarcomeres, muscle, skeletal, animals, animals, genetically modified, humans, drosophila melanogaster, chronobiology disorders, obesity, disease models, animal, treatment outcome, fasting, energy metabolism, circadian rhythm, female, male, diet, high-fat, shift work schedule, metabolic syndrome
10 authors
From US
- Jesús E. VillanuevaSan Diego State University
- Christopher LiveloSan Diego State University
- Adriana S. TrujilloSan Diego State University
- Sahaana ChandranSan Diego State University
- Brendon WoodworthSan Diego State University
- Leo AndradeSalk Institute for Biological Studies
Abstract
Pathological obesity can result from genetic predisposition, obesogenic diet, and circadian rhythm disruption. Obesity compromises function of muscle, which accounts for a majority of body mass. Behavioral intervention that can counteract obesity arising from genetic, diet or circadian disruption and can improve muscle function holds untapped potential to combat the obesity epidemic. Here we show that Drosophila melanogaster (fruit fly) subject to obesogenic challenges exhibits metabolic disease phenotypes in skeletal muscle; sarcomere disorganization, mitochondrial deformation, upregulation of Phospho-AKT level, aberrant intramuscular lipid infiltration, and insulin resistance. Imposing time-restricted feeding (TRF) paradigm in which flies were fed for 12 h during the day counteracts obesity-induced dysmetabolism and improves muscle performance by suppressing intramuscular fat deposits, Phospho-AKT level, mitochondrial aberrations, and markers of insulin resistance. Importantly, TRF was effective even in an irregular lighting schedule mimicking shiftwork. Hence, TRF is an effective dietary intervention for combating metabolic dysfunction arising from multiple causes.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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