A Single Dose of Dietary Nitrate Increases Maximal Knee Extensor Angular Velocity and Power in Healthy Older Men and Women
Coggan AR, Hoffman RL, Gray DA, Moorthi RN, Thomas DP, Leibowitz JL, Thies D, Peterson LR
The journals of gerontology. Series A, Biological sciences and medical sciences · 47 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- Ministry of Education, India
- Government
- National Institutes of Health
- Government
- National Institute on Aging
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Government
- National Center for Advancing Translational Sciences
- Government
- NCATS NIH HHS
- Government
- NIDDK NIH HHS
- Government
- NIA NIH HHS
- Government
- NHLBI NIH HHS
- Government
- NIAMS NIH HHS
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK056341); National Center for Advancing Translational Sciences (UL1TR002529); National Center for Advancing Translational Sciences (UL1TR002345); National Institute of Diabetes and Digestive and Kidney Diseases (K23 DK102824); National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR072581); National Institute on Aging (R21 AG053606); National Heart, Lung, and Blood Institute (R34HL138253); National Institutes of Health (P30AR072581); National Institutes of Health (UL1-TR002345); National Institutes of Health (UL1 TR002529); National Institutes of Health (TR002345); National Institutes of Health (R34HL138253); National Institutes of Health (AG053606); National Institutes of Health (R21 AG053606); National Institutes of Health (AR072581); National Institutes of Health (TR002529); National Institutes of Health (K23 DK102824)
Based on 12 listed funder(s).
Publication
- Published
- 2019-06-24 · J Gerontol A Biol Sci Med Sci · vol. 75 · issue 6 · pp. 1154–1160
- Publisher
- Oxford University Press
- Cited
- 61 citations · more than 94% of similar papers · 3.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 41 works
- Access
- Free to read
- Research areas
- Nitric Oxide and Endothelin Effects · Exercise and Physiological Responses · Muscle Physiology and Disorders
- Keywords
- Medicine, Crossover study, Placebo, Internal medicine, Ingestion, Nitric oxide, Population, Endocrinology, Bioavailability, Cardiology, Pharmacology
- MeSH
- knee, humans, nitrates, double-blind method, movement, muscle contraction, dietary supplements, aged, female, male, muscle strength, muscle strength dynamometer
8 authors
From US
- Andrew R. Coggan · correspondingIndiana University – Purdue University Indianapolis
- Richard Leigh HoffmanIndiana University – Purdue University Indianapolis
- Derrick A. GrayIndiana University – Purdue University Indianapolis
- Ranjani N. MoorthiIndiana University – Purdue University Indianapolis
- Deepak P. ThomasWashington University in St. Louis
- Joshua L. LeibowitzWashington University in St. Louis
Abstract
Background
Aging results in reductions in maximal muscular strength, speed, and power, which often lead to functional limitations highly predictive of disability, institutionalization, and mortality in elderly adults. This may be partially due to reduced nitric oxide (NO) bioavailability. We, therefore, hypothesized that dietary nitrate (NO3-), a source of NO via the NO3- → nitrite (NO2-) → NO enterosalivary pathway, could increase muscle contractile function in older subjects.
Methods
Twelve healthy older (age 71 ± 5 years) men and women were studied using a randomized, double-blind, placebo-controlled, crossover design. After fasting overnight, subjects were tested 2 hours after ingesting beetroot juice containing or devoid of 13.4 ± 1.6 mmol NO3-. Plasma NO3- and NO2- and breath NO were measured periodically, and muscle function was determined using isokinetic dynamometry.
Results
N O 3 - ingestion increased (p < .001) plasma NO3-, plasma NO2-, and breath NO by 1,051% ± 433%, 138% ± 149%, and 111% ± 115%, respectively. Maximal velocity of knee extension increased (p < .01) by 10.9% ± 12.1%. Maximal knee extensor power increased (p < .05) by 4.4% ± 7.8%.
Conclusions
Acute dietary NO3- intake improves maximal knee extensor angular velocity and power in older individuals. These findings may have important implications for this population, in whom diminished muscle function can lead to functional limitations, dependence, and even premature death.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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