Funded in part by AlzChem AG
Creatine Supplementation (3 g/d) and Bone Health in Older Women: A 2-Year, Randomized, Placebo-Controlled Trial
Sales LP, Pinto AJ, Rodrigues SF, Alvarenga JC, Gonçalves N, Sampaio-Barros MM, Benatti FB, Gualano B, Rodrigues Pereira RM
The journals of gerontology. Series A, Biological sciences and medical sciences · 27 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Industry funded
- Government
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Company
- AlzChem AG
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior
- Grants
- Fundação de Amparo à Pesquisa do Estado de São Paulo (15/26937-4); Fundação de Amparo à Pesquisa do Estado de São Paulo (15/14698-5)
Based on 4 listed funder(s).
Publication
- Published
- 2019-06-29 · J Gerontol A Biol Sci Med Sci · vol. 75 · issue 5 · pp. 931–938
- Publisher
- Oxford University Press
- Cited
- 39 citations · more than 83% of similar papers · 1.8× the field average
- References
- 38 works
- Access
- Paywalled
- Research areas
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Bone health and osteoporosis research
- Keywords
- Creatine, Osteopenia, Medicine, Lean body mass, Bone mineral, Placebo, Femoral neck, Osteoporosis, Randomized controlled trial, Population, Creatine Monohydrate, Internal medicine, Physical therapy, Body weight
- MeSH
- humans, bone diseases, metabolic, osteoporosis, creatine, absorptiometry, photon, double-blind method, accidental falls, postmenopause, bone density, aged, middle aged, brazil, female, fractures, bone, muscle strength
9 authors
From BR
- Lucas Peixoto SalesHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Ana Jéssica PintoHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Samara Ferrari RodriguesHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Jackeline Couto AlvarengaHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Natália GonçalvesCentrus Diagnósticos por Imagem
- Marília M Sampaio-BarrosHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Abstract
Background
Creatine supplementation could be a nonexpensive, safe, and effective dietary intervention to counteract bone loss. The aim of this study was to investigate whether long-term creatine supplementation can improve bone health in older, postmenopausal women.
Methods
A double-blind, placebo-controlled, parallel-group, randomized trial was conducted between November 2011 and December 2017 in Sao Paulo, Brazil. Two hundred postmenopausal women with osteopenia were randomly allocated to receive either creatine monohydrate (3 g/d) or placebo for 2 years. At baseline and after 12 and 24 months, we assessed areal bone mineral density (aBMD; primary outcome), lean and fat mass (through dual X-ray absorptiometry), volumetric BMD and bone microarchitecture parameters, biochemical bone markers, physical function and strength, and the number of falls and fractures. Possible adverse effects were self-reported.
Results
Lumbar spine (p .050). Bone markers, microarchitecture parameters, and the number of falls/fractures were not changed with creatine (all p > .050). Lean mass and appendicular skeletal muscle mass increased throughout the intervention (p < .001), with no additive effect of creatine (p = .731 and p = .397, respectively). Creatine did not affect health-related laboratory parameters.
Conclusion
Creatine supplementation more than 2 years did not improve bone health in older, postmenopausal women with osteopenia, nor did it affect lean mass or muscle function in this population. This refutes the long-lasting notion that this dietary supplement alone has osteogenic or anabolic properties in the long run.
Clinical trial registry
Clinicaltrials.gov: NCT: 01472393.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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