Transcranial photobiomodulation with 1064-nm laser modulates brain electroencephalogram rhythms
Wang X, Dmochowski JP, Zeng L, Kallioniemi E, Husain M, Gonzalez-Lima F, Liu H
Neurophotonics · 60 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of Texas System
- Government
- National Institutes of Health
- Government
- National Institute of Mental Health
- Government
- NIMH NIH HHS
- Grants
- National Institute of Mental Health (RF1 MH114285); National Institutes of Health (1rf1mh114285-01)
Based on 4 listed funder(s).
Publication
- Published
- 2019-06-13 · Neurophotonics · vol. 6 · issue 02 · p. 1
- Publisher
- SPIE
- Cited
- 96 citations · more than 97% of similar papers · 5.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 69 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Laser Applications in Dentistry and Medicine · Optical Imaging and Spectroscopy Techniques · Photoreceptor and optogenetics research
- Keywords
- Electroencephalography, Scalp, Human brain, Neuroscience, Electrophysiology, Brain activity and meditation, Beta Rhythm, EEG-fMRI, Alpha rhythm, Neurophysiology, Forehead, Psychology, Medicine, Anatomy
7 authors
From US
- Xinlong WangThe University of Texas at Arlington
- Jacek DmochowskiCity College of New York
- Li ZengTexas A&M University
- Elisa KallioniemiThe University of Texas Southwestern Medical Center
- Mustafa M. HusainThe University of Texas Southwestern Medical Center
- Francisco Gonzalez-LimaThe University of Texas at Austin
Abstract
Noninvasive transcranial photobiomodulation (tPBM) with a 1064-nm laser has been reported to improve human performance on cognitive tasks as well as locally upregulate cerebral oxygen metabolism and hemodynamics. However, it is unknown whether 1064-nm tPBM also modulates electrophysiology, and specifically neural oscillations, in the human brain. The hypothesis guiding our study is that applying 1064-nm tPBM of the right prefrontal cortex enhances neurophysiological rhythms at specific frequency bands in the human brain under resting conditions. To test this hypothesis, we recorded the 64-channel scalp electroencephalogram (EEG) before, during, and after the application of 11 min of 4-cm-diameter tPBM (CW 1064-nm laser with 162 mW / cm 2 and 107 J / cm 2 ) to the right forehead of human subjects ( n = 20 ) using a within-subject, sham-controlled design. Time-resolved scalp topographies of EEG power at five frequency bands were computed to examine the tPBM-induced EEG power changes across the scalp. The results show time-dependent, significant increases of EEG spectral powers at the alpha (8 to 13 Hz) and beta (13 to 30 Hz) bands at broad scalp regions, exhibiting a front-to-back pattern. The findings provide the first sham-controlled topographic mapping that tPBM increases the strength of electrophysiological oscillations (alpha and beta bands) while also shedding light on the mechanisms of tPBM in the human brain.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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