Effect of egg consumption on inflammatory markers: a systematic review and meta-analysis of randomized controlled clinical trials
Sajadi Hezaveh Z, Sikaroudi MK, Vafa M, Clayton ZS, Soltani S
Journal of the science of food and agriculture · 13 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIDDK NIH HHS
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007135)
Based on 2 listed funder(s).
Publication
- Published
- 2019-07-01 · J Sci Food Agric · vol. 99 · issue 15 · pp. 6663–6670
- Publisher
- Wiley
- Cited
- 18 citations · more than 49% of similar papers · 0.4× the field average
- References
- 59 works
- Access
- Open access (repository copy)
- Research areas
- Adipokines, Inflammation, and Metabolic Diseases · Fatty Acid Research and Health · Nutritional Studies and Diet
- Keywords
- Meta-analysis, Medicine, Randomized controlled trial, Cochrane Library, Internal medicine, Inflammation, Clinical trial, C-reactive protein, Gastroenterology, Tumor necrosis factor alpha
- MeSH
- animals, chickens, humans, inflammation, tumor necrosis factor-alpha, c-reactive protein, interleukin-6, eggs, adult, aged, middle aged, female, male, randomized controlled trials as topic, young adult, biomarkers
5 authors
From IR, US
- Zohreh Sajadi HezavehIran University of Medical Sciences
- Masoumeh Khalighi SikaroudiIran University of Medical Sciences
- Mohammadreza VafaIran University of Medical Sciences
- Zachary Stephen ClaytonUniversity of Colorado Boulder
- Sepideh Soltani · correspondingShahid Sadoughi University of Medical Sciences and Health Services
Abstract
There is little evidence about whether eggs affect inflammation. The aim of this meta-analysis was to explore the effects of egg consumption on inflammation. A systematic search of online databases (Institute for Scientific Information (ISI), Scopus, Ovid, PubMed, Cochrane) was used to gather clinical trials that assessed the effect of egg consumption on circulating inflammatory biomarkers. Using a random-effects model, pooled weighted mean differences (WMD) and corresponding standard deviations (SD) were calculated. Of the 21 eligible studies found, nine trials were eligible for analysis. Eight trials assessed high-sensitivity C-reactive protein (hs-CRP), four trials assessed interleukin-6 (IL-6), and five trials assessed tumor necrosis factor-alpha (TNF-α). Egg consumption did not affect hs-CRP (WMD 0.24 mg/L; 95% CI: -0.43, 0.90; I2 = 53.8; P = 0.48), IL-6 (WMD 0.20 pg/mL; 95% CI: -0.71, 1.11; I2 = 69.3; P = 0.50), and TNF-α (WMD: -0.38 pg/mL; 95% CI: -0.87, 0.10; I2 = 0.00; P = 0.12) relative to controls. Overall, this meta-analysis revealed that egg consumption had no significant effect on serum biomarkers of inflammation in adults. © 2019 Society of Chemical Industry.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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