Funded in part by MTI Biotech, MTI Biotech Inc.
Time-restricted feeding plus resistance training in active females: a randomized trial
Tinsley GM, Moore ML, Graybeal AJ, Paoli A, Kim Y, Gonzales JU, Harry JR, VanDusseldorp TA, Kennedy DN, Cruz MR
The American journal of clinical nutrition · 173 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- University or hospital
- Texas Tech University
- Company
- MTI Biotech
- Company
- MTI Biotech Inc.
Based on 3 listed funder(s).
Publication
- Published
- 2019-05-31 · Am J Clin Nutr · vol. 110 · issue 3 · pp. 628–640
- Publisher
- Elsevier BV
- Cited
- 223 citations · more than 99% of similar papers · 13.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 58 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Muscle metabolism and nutrition
- Keywords
- Calorie, Randomized controlled trial, Medicine, Placebo, Internal medicine, Animal science, Endocrinology, Resistance training, Muscle hypertrophy, Biology
- MeSH
- humans, body composition, time factors, adult, female, resistance training, young adult, meals
10 authors
From US, IT
- Grant M. Tinsley · correspondingTexas Tech University
- Michael Lane MooreTexas Tech University
- Austin J. GraybealTexas Tech University
- Antonio PaoliUniversity of Padua
- Youngdeok KimTexas Tech University
- Joaquin U. GonzalesTexas Tech University
Abstract
Background
A very limited amount of research has examined intermittent fasting (IF) programs, such as time-restricted feeding (TRF), in active populations.
Objective
Our objective was to examine the effects of TRF, with or without β-hydroxy β-methylbutyrate (HMB) supplementation, during resistance training (RT).
Methods
This study employed a randomized, placebo-controlled, reduced factorial design and was double-blind with respect to supplementation in TRF groups. Resistance-trained females were randomly assigned to a control diet (CD), TRF, or TRF plus 3 g/d HMB (TRFHMB). TRF groups consumed all calories between 1200 h and 2000 h, whereas the CD group ate regularly from breakfast until the end of the day. All groups completed 8 wk of supervised RT and consumed supplemental whey protein. Body composition, muscular performance, dietary intake, physical activity, and physiological variables were assessed. Data were analyzed prior to unblinding using mixed models and both intention-to-treat (ITT) and per protocol (PP) frameworks.
Results
Forty participants were included in ITT, and 24 were included in PP. Energy and protein intake (1.6 g/kg/d) did not differ between groups despite different feeding durations (TRF and TRFHMB: ∼7.5 h/d; CD: ∼13 h/d). Comparable fat-free mass (FFM) accretion (+2% to 3% relative to baseline) and skeletal muscle hypertrophy occurred in all groups. Differential effects on fat mass (CD: +2%; TRF: -2% to -4%; TRFHMB: -4% to -7%) were statistically significant in the PP analysis, but not ITT. Muscular performance improved without differences between groups. No changes in physiological variables occurred in any group, and minimal side effects were reported.
Conclusions
IF, in the form of TRF, did not attenuate RT adaptations in resistance-trained females. Similar FFM accretion, skeletal muscle hypertrophy, and muscular performance improvements can be achieved with dramatically different feeding programs that contain similar energy and protein content during RT. Supplemental HMB during fasting periods of TRF did not definitively improve outcomes. This study was prospectively registered at clinicaltrials.gov as NCT03404271.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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