Impaired microvascular reactivity after eccentric muscle contractions is not restored by acute ingestion of antioxidants or dietary nitrate
Larsen RG, Thomsen JM, Hirata RP, Steffensen R, Poulsen ER, Frøkjaer JB, Graven-Nielsen T
Physiological reports · 22 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Gigtforeningen
- Government
- National Research Foundation
- Government
- Danmarks Grundforskningsfond
- Government
- Kulturministeriet
- Grants
- Kulturministeriet (TAKT2014-361); Danmarks Grundforskningsfond (DNRF121); Gigtforeningen (R151-A4608); National Research Foundation (DNRF121)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-07-01 · Physiol Rep · vol. 7 · issue 13 · p. e14162
- Publisher
- Wiley
- Cited
- 26 citations · more than 90% of similar papers · 3.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 56 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Cardiovascular and exercise physiology · Heart Rate Variability and Autonomic Control · Exercise and Physiological Responses
- Keywords
- Medicine, Eccentric, Nitric oxide, Internal medicine, Placebo, Oxidative stress, Isometric exercise, Eccentric exercise, Vasodilation, Blood flow, Cardiology, Endocrinology, Anesthesia, Muscle damage, Pathology
- MeSH
- muscle, skeletal, humans, beta vulgaris, hyperemia, antioxidants, vasodilation, isometric contraction, adult, female, male, microvessels, fruit and vegetable juices
7 authors
From DK
- Ryan Godsk Larsen · correspondingAalborg University
- Jens M. ThomsenAalborg University
- Rogério Pessoto HirataAalborg University
- Rudi SteffensenAalborg University Hospital
- Eva R. PoulsenAalborg University Hospital
- Jens Brøndum FrøkjærAalborg University Hospital; Aalborg University
Abstract
Unaccustomed eccentric exercise leads to impaired microvascular function but the underlying mechanism is unknown. In this study, we evaluated the role of oxidative stress and of nitric oxide (NO) bioavailability. Thirty young men and women performed eccentric contractions of the tibialis anterior (TA) muscle (ECC), with the contralateral leg serving as nonexercising control (CON). Participants were randomized into three groups ingesting an antioxidant cocktail (AO), beetroot juice (BR) or placebo 46 h postexercise. At baseline and 48 h postexercise, hyperemic responses to brief muscle contractions and 5 min of cuff occlusion were assessed bilaterally in the TA muscles using blood oxygen level dependent (BOLD) magnetic resonance imaging. Eccentric contractions resulted in delayed time-to-peak (~22%; P < 0.001), blunted peak (~21%; P < 0.001) and prolonged time-to-half relaxation (~12%, P < 0.001) in the BOLD response to brief contractions, with no effects of AO or BR, and no changes in CON. Postocclusive time-to-peak was also delayed (~54%; P < 0.001) in ECC, with no effects of AO or BR, and no changes in CON. Impaired microvascular reactivity after eccentric contractions is confined to the exercised tissue, and is not restored with acute ingestion of AO or BR. Impairments in microvascular reactivity after unaccustomed eccentric contractions may result from structural changes within the microvasculature that can diminish muscle blood flow regulation during intermittent activities requiring prompt adjustments in oxygen delivery.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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