Profile of Fatty Acids, Tocopherols, Phytosterols and Polyphenols in Mediterranean Oils (Argan Oils, Olive Oils, Milk Thistle Seed Oils and Nigella Seed Oil) and Evaluation of their Antioxidant and Cytoprotective Activities
Zarrouk A, Martine L, Grégoire S, Nury T, Meddeb W, Camus E, Badreddine A, Durand P, Namsi A, Yammine A, Nasser B, Mejri M, Bretillon L, Mackrill JJ, Cherkaoui-Malki M, Hammami M, Lizard G
Current pharmaceutical design · 55 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2019-07-06 · Curr Pharm Des · vol. 25 · issue 15 · pp. 1791–1805
- Publisher
- Bentham Science Publishers
- Cited
- 96 citations · more than 99% of similar papers · 13.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 84 works
- Access
- Paywalled
- Research areas
- Nigella sativa pharmacological applications · Cholesterol and Lipid Metabolism · Essential Oils and Antimicrobial Activity
- Keywords
- Phytosterol, Polyphenol, Hydroxytyrosol, Food science, Chemistry, Linoleic acid, Oleic acid, Fatty acid, Antioxidant, Tocopherol, Vitamin E, Biochemistry
- MeSH
- cell line, animals, humans, mice, nigella, seeds, phytosterols, fatty acids, plant oils, tocopherols, antioxidants, polyphenols, olive oil, silybum marianum
17 authors
From TN, FR, MA, IE
- Amira ZarroukUniversity of Monastir
- Lucy MartineCentre National de la Recherche Scientifique; Université de Bourgogne; Centre des Sciences du Goût et de l'Alimentation
- Stéphane GregoireCentre National de la Recherche Scientifique; Université de Bourgogne; Centre des Sciences du Goût et de l'Alimentation
- Thomas NuryInserm; Université de Bourgogne
- Wiem MeddebInstitut Supérieur de Biotechnologie de Sfax
- Emmanuelle CamusLaboratoires Spiral (France)
Abstract
Background
The effects of vegetable oils on human health depend on their components. Therefore, their profiles of lipid nutrients and polyphenols were determined.
Objective
To establish and compare the fatty acid, tocopherol, phytosterol and polyphenol profiles of Mediterranean oils: cosmetic and dietary argan oils (AO; Morocco: Agadir, Berkane); olive oils (OO; Morocco, Spain, Tunisia); milk thistle seed oils (MTSO; Tunisia: Bizerte, Sousse, Zaghouane); nigella seed oil (NSO).
Methods
The biochemical profiles were determined by gas chromatography-flame ionization, high performance liquid chromatography and gas chromatography, coupled with mass spectrometry as required. The antioxidant and cytoprotective activities were evaluated with the KRL (Kit Radicaux Libres) and the fluorescein diacetate tests on nerve cells treated with 7-ketocholesterol (7KC).
Results
The fatty acid profile revealed high linoleic acid (C18:2 n-6) content in AO, OO, MTSO and NSO. The highest levels of oleic acid (C18:1 n-9) were found in AO and OO. The tocopherol profile showed that Agadir AO contained the highest amount of α-tocopherol, also present at high level in MTSO and Tunisian OO; Berkane AO was rich in γ-tocopherol. The phytosterol profile indicated that β-sitosterol was predominant in the oils, except AO; spinasterol was only present in AO. Polyphenol profiles underlined that OO was the richest in polyphenols; hydroxytyrosol was only found in OO; few polyphenols were detected in AO. The oils studied have antioxidant activities, and all of them, except NSO, prevented 7KC-induced cell death. The antioxidant characteristics of AO were positively correlated with procatechic acid and compestanol levels.
Conclusion
Based on their biochemical profiles, antioxidant and cytoprotective characteristics, AO, OO, and MTSO are potentially beneficial to human health.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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