Magnesium intake and lung cancer risk: A systematic review and meta-analysis
Dana N, Karimi R, Mansourian M, Javanmard SH, Laher I, Vaseghi G
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 11 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2019-07-15 · Int J Vitam Nutr Res · vol. 91 · issue 5-6 · pp. 539–546
- Publisher
- Hogrefe Verlag
- Cited
- 17 citations · more than 38% of similar papers · 0.1× the field average
- References
- 36 works
- Access
- Paywalled
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Biomarkers in Disease Mechanisms
- Keywords
- Lung cancer, Medicine, Meta-analysis, Relative risk, Internal medicine, Gastroenterology, Subgroup analysis, Cancer, Risk factor, Incidence (geometry), Magnesium, Confidence interval, Chemistry
- MeSH
- lung, humans, lung neoplasms, magnesium, risk, risk factors, nutritional status
6 authors
From IR, CA
- Nasim DanaIsfahan University of Medical Sciences
- Raheleh KarimiIsfahan University of Medical Sciences
- Marjan MansourianIsfahan University of Medical Sciences
- Shaghayegh Haghjooy JavanmardIsfahan University of Medical Sciences
- Ismail LaherIsfahan University of Medical Sciences; University of British Columbia
- Golnaz VaseghiIsfahan University of Medical Sciences
Abstract
Magnesium may reduce the risk of lung cancer by affecting cell proliferation, inflammation and by preserving lung function; however, the results of epidemiological studies on the potential benefits of magnesium in lung pathology are inconclusive. We conducted this meta-analysis to investigate the association between magnesium intake and the risk of lung cancer. A total of 5 studies were extracted from PubMed, SCOPUS, and the Cochrane Review (to May 2018). These studies involved 58,5821 participants with 8,977 lung cancer cases. The pooled relative risk (RR) indicated a significant association between lung cancer incidence and magnesium intake (RR = 0.88, 95% CI = 0.79 to 0.98; p = 0.018). To investigate the cause of heterogeneity of these studies (I2 = 75.8%, p p = 0.034). Increasing magnesium intake doses to over 300 mg/d did not reduce the incidence of lung cancer (RR = 0.89, 95% CI = 0.78 to 1.01; p = 0.076). Our meta-analysis suggests that magnesium intake of less than 300 mg/d may have protective effects in lung cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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