Association between consumption of ultra-processed foods and serum C-reactive protein levels: cross-sectional results from the ELSA-Brasil study
Lopes AEDSC, Araújo LF, Levy RB, Barreto SM, Giatti L
Sao Paulo medical journal = Revista paulista de medicina · 60 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
Based on 1 listed funder(s).
Publication
- Published
- 2019-04-01 · Sao Paulo Med J · vol. 137 · issue 2 · pp. 169–176
- Publisher
- Medical Association of São Paulo
- Cited
- 84 citations · more than 97% of similar papers · 7.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 40 works
- Access
- Open access (free to publish) · CC-BY
- Research areas
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Nutrition, Genetics, and Disease
- Keywords
- Medicine, Body mass index, Obesity, Cross-sectional study, Confidence interval, C-reactive protein, National Health and Nutrition Examination Survey, Environmental health, Food frequency questionnaire, Internal medicine, Inflammation, Population
- MeSH
- humans, c-reactive protein, body mass index, nutrition surveys, cohort studies, longitudinal studies, cross-sectional studies, feeding behavior, energy intake, nutritive value, socioeconomic factors, adult, aged, middle aged, brazil, female, male, fast foods
5 authors
From BR
- Aline Ester da Silva Cruz LopesUniversidade Federal de Ouro Preto
- Larissa Fortunato AraújoUniversidade Federal de Minas Gerais; Universidade Federal do Ceará
- Renata Bertazzi LevyUniversidade de São Paulo; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Sandhi Maria BarretoUniversidade Federal de Minas Gerais; Hospital das Clínicas da Universidade Federal de Minas Gerais
- Luana GiattiUniversidade Federal de Minas Gerais; Hospital das Clínicas da Universidade Federal de Minas Gerais
Abstract
Background
There may be a direct association between consumption of ultra-processed foods and C-reactive protein (CRP) levels, under the assumption that the high glycemic index of these food products could stimulate the entire chronic inflammation cascade, along with an indirect association mediated by obesity. The types of food consumed, including ultra-processed products, strongly influence obesity, and are also associated with higher serum CRP levels.
Objective
Our aim was to investigate whether the caloric contribution of ultra-processed foods to diet is associated with CRP levels, independent of body mass index (BMI).
Design and setting
Cross-sectional analysis on the Longitudinal Study of Adult Health (ELSA-Brasil) baseline cohort (2008-2010).
Methods
Dietary information, obtained through a food frequency questionnaire, was used to estimate the percentage of energy contribution from ultra-processed food to individuals' total caloric intake. CRP levels were the response variable. Sex-specific associations were estimated using generalized linear models with gamma distribution and log-link function.
Results
Ultra-processed food accounted for 20% of total energy intake. Among men, after adjustments for sociodemographic characteristics, there was no association between ultra-processed food intake and CRP levels. Among women, after adjustment for sociodemographic characteristics, smoking and physical activity, the highest tercile of ultra-processed food intake was associated with mean CRP levels that were 14% higher (95% confidence interval: 1.04-1.24) than those of the lowest tercile. However, after considering BMI, this association lost statistical significance.
Conclusion
Our findings suggest that the positive association of ultra-processed food consumption with CRP levels among women seems to be mediated by the presence of adiposity.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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