The Influence of Red Meat on Colorectal Cancer Occurrence Is Dependent on the Genetic Polymorphisms of S-Glutathione Transferase Genes
Klusek J, Nasierowska-Guttmejer A, Kowalik A, Wawrzycka I, Chrapek M, Lewitowicz P, Radowicz-Chil A, Klusek J, Głuszek S
Nutrients · 17 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Narodowe Centrum Nauki
- University or hospital
- Uniwersytet Jana Kochanowskiego w Kielcach
- Government
- National Institutes of Health
- Grants
- Narodowe Centrum Nauki (UMO-2013/09/B/NZ7/03910)
Based on 3 listed funder(s).
Publication
- Published
- 2019-07-22 · Nutrients · vol. 11 · issue 7 · p. 1682
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 20 citations · more than 87% of similar papers · 2.1× the field average
- References
- 21 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutrition, Genetics, and Disease · Glutathione Transferases and Polymorphisms · Genomics, phytochemicals, and oxidative stress
- Keywords
- Glutathione S-transferase, Colorectal cancer, Gene, Biology, Glutathione transferase, Genetics, Transferase, Glutathione, Cancer, Enzyme, Biochemistry
- MeSH
- animals, humans, colorectal neoplasms, genetic predisposition to disease, glutathione transferase, diet, nutrition assessment, genotype, polymorphism, genetic, adult, aged, aged, 80 and over, middle aged, poland, female, male, red meat
9 authors
From PL
- Justyna E. Klusek · correspondingJan Kochanowski University
- Anna Nasierowska-GuttmejerJan Kochanowski University
- Artur KowalikHoly Cross University
- Iwona WawrzyckaJan Kochanowski University
- Magdalena ChrapekJan Kochanowski University; Institute of Mathematics
- Piotr LewitowiczJan Kochanowski University
Abstract
Background
It is postulated that both individual genotype and environmental factors such as diet may modify the risk of developing colorectal cancer (CRC). The influences of GST gene polymorphism and red meat intake on CRC occurrence in the Polish population were analyzed in this study.
Methods
Genotyping was performed with the qPCR method.
Results
A high frequency of meat consumption was associated with an over 2-fold increase in the risk of colorectal cancer odds ratio (OR) adjusted for sex and age = 2.4, 95% confidence interval (CI); 1.3-4.4). However, after analyzing the genetic profiles, in the absence of polymorphisms of all three analyzed genes, there was no association between a high frequency of meat consumption and the occurrence of CRC. In the case of GSTM1 gene polymorphism, the high frequency of meat consumption increased the risk of CRC by almost more than 4 times (OR adjusted for sex and age = 3.8, 95% CI: 1.6-9.1). For GSTP1 gene polymorphism, a 3-fold increase in CRC risk was observed with a high frequency of meat consumption (OR adjusted for sex and age = 3.4, 95% CI: 1.4-8.1). In the case of GSTT1 gene polymorphism, the increase in risk of CRC was not statistically significant (OR adjusted for sex and age = 1.9, 95% CI: 0.4-8.5).
Conclusions
The frequency of red meat intake in non-smokers increases the risk of colon cancer in the case of GST gene polymorphisms.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.