Elevation of serum creatinine in a renal transplant patient following oral creatine supplementation
Law JP, Di Gerlando S, Pankhurst T, Kamesh L
Clinical kidney journal · 5 citations
How it was studied
- Design
- Case report (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2018-09-10 · Clin Kidney J · vol. 12 · issue 4 · pp. 600–601
- Publisher
- Oxford University Press
- Cited
- 6 citations · more than 50% of similar papers · 0.2× the field average
- References
- 6 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Muscle metabolism and nutrition · Metabolism and Genetic Disorders · Pharmacological Effects and Toxicity Studies
- Keywords
- Medicine, Creatinine, Creatine, Renal transplant, Urology, Internal medicine, Intensive care medicine, Kidney, Gastroenterology
4 authors
From GB
- Jonathan P. Law · correspondingUniversity Hospitals Birmingham NHS Foundation Trust
- Saveria Di GerlandoUniversity Hospitals Birmingham NHS Foundation Trust
- Tanya PankhurstUniversity Hospitals Birmingham NHS Foundation Trust
- Lavanya KameshUniversity Hospitals Birmingham NHS Foundation Trust
Abstract
We report the case of a renal transplant recipient presenting with elevated serum creatinine levels whilst taking oral creatine ethyl ester (CEE), but not creatine monohydrate (CM). Standard investigations for allograft dysfunction, including Doppler ultrasound and renal biopsy, were normal. Serum creatinine normalized following cessation of the supplement. CM is poorly absorbed and does not affect creatinine. In contrast, CEE is converted and absorbed as creatinine, elevating serum levels. In such cases, creatinine is not a valid surrogate for glomerular filtration rate (GFR). Alternate methods of GFR measurement should be considered and a rigorous clinical and drug history taken.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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