Relationship between 25-Hydroxyvitamin D, bone density, and Parkinson's disease symptoms
Zhang HJ, Zhang JR, Mao CJ, Li K, Wang F, Chen J, Liu CF
Acta neurologica Scandinavica · 29 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Government of Jiangsu Province
- Government
- National Key Research and Development Program of China
- University or hospital
- Suzhou Clinical Research Center of Neurological Disease
- Government
- Social development projects in Jiangsu Province
- Government
- National Key R&D Program of China
- Government
- Jiangsu Provincial Medical Key Discipline Project
- Grants
- Government of Jiangsu Province (BE2018658); National Key Research and Development Program of China (2017YFC 0909100); Government of Jiangsu Province (BE2017653); Government of Jiangsu Province (ZDXKB2016022)
Based on 6 listed funder(s).
Publication
- Published
- 2019-08-06 · Acta Neurol Scand · vol. 140 · issue 4 · pp. 274–280
- Publisher
- Wiley
- Cited
- 39 citations · more than 89% of similar papers · 2.4× the field average
- References
- 48 works
- Access
- Free to read
- Research areas
- Vitamin D Research Studies · Bone health and osteoporosis research · Parathyroid Disorders and Treatments
- Keywords
- Medicine, Internal medicine, Vitamin D and neurology, Femoral neck, Bone mineral, Depression (economics), Pittsburgh Sleep Quality Index, Endocrinology, vitamin D deficiency, Anxiety, Parkinson's disease, Bone density, Gastroenterology, Osteoporosis, Disease, Insomnia, Sleep quality, Psychiatry
- MeSH
- femur neck, lumbar vertebrae, humans, parkinson disease, vitamin d deficiency, vitamin d, absorptiometry, photon, accidental falls, bone density, aged, middle aged, female, male
7 authors
From CN
- Huijun ZhangSoochow University; Second Affiliated Hospital of Soochow University
- Jin‐Ru ZhangSoochow University; Second Affiliated Hospital of Soochow University
- Chengjie MaoSoochow University; Second Affiliated Hospital of Soochow University
- Kai LiSoochow University; Second Affiliated Hospital of Soochow University
- Fen WangSoochow University
- Jing Chen · correspondingSoochow University; Second Affiliated Hospital of Soochow University
Abstract
Objectives
Vitamin D deficiency is widespread in patients with Parkinson's disease (PD). Our aim was to determine whether serum vitamin D levels correlated with bone mineral density (BMD) and non-motor symptoms in patients with PD.
Materials & methods
A consecutive series of 182 patients with PD and 185 healthy controls were included. Serum 25-hydroxyvitamin D (25[OH]D) levels were measured by immunoassay, while BMD of the lumbar spine and femoral neck was measured by dual-energy X-ray absorptiometry. Associations between serum vitamin D levels and clinical data were evaluated using partial correlation analysis.
Results
Patients with PD had significantly lower serum 25(OH)D levels relative to healthy controls (49.75 ± 14.11 vs 43.40 ± 16.51, P < 0.001). Furthermore, PD patients with lower vitamin D levels had a significantly higher frequency of falls (P = 0.033) and insomnia (P = 0.015). They also had significantly higher scores for the Pittsburgh Sleep Quality Index (PSQI; P = 0.014), depression (P = 0.020), and anxiety (P = 0.009). Finally, patients with PD also had a significantly lower mean BMD of the lumbar spine (P = 0.011) and femoral neck (P < 0.001). After adjusting for age, sex, and body mass index, vitamin D levels significantly correlated with falls, insomnia, and scores for the PSQI, depression, and anxiety.
Conclusions
In patients with PD, vitamin D levels significantly correlated with falls and some non-motor symptoms. However, no associations were found between BMD and the serum 25(OH)D levels in patients with PD. Thus, vitamin D supplementation is a potential therapeutic for non-motor PD symptoms.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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