Impact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race
Córdova A, Mielgo-Ayuso J, Roche E, Caballero-García A, Fernandez-Lázaro D
Nutrients · 14 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2019-08-16 · Nutrients · vol. 11 · issue 8 · p. 1927
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 23 citations · more than 82% of similar papers · 1.6× the field average
- References
- 40 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Sports injuries and prevention · Sports Performance and Training
- Keywords
- Magnesium, Creatine kinase, Internal medicine, Endocrinology, Myoglobin, Aspartate transaminase, Creatinine, Lactate dehydrogenase, Anabolism, Medicine, Biology, Chemistry, Biochemistry, Enzyme, Alkaline phosphatase
- MeSH
- humans, muscular diseases, magnesium, bicycling, dietary supplements, adult, male, athletes
5 authors
From ES
- Alfredo C CordovaUniversidad de Valladolid
- Juan Mielgo‐Ayuso · correspondingUniversidad de Valladolid
- Enrique RocheInstituto de Salud Carlos III; Centro de Investigación Biomédica en Red; Instituto de investigación sanitaria y biomédica de Alicante
- Alberto Caballero-GarcíaUniversidad de Valladolid
- Diego Fernández‐LázaroUniversidad de Valladolid
Abstract
Magnesium is a cofactor of different enzymatic reactions involved in anabolic and catabolic processes that affect muscular performance during exercise. In addition, it has been suggested that magnesium could participate in maintaining muscle integrity during demanding effort. The main purpose of this study was to analyze the effects of magnesium supplementation in preventing muscle damage in professional cyclists taking part in a 21-day cycling stage race. Eighteen male professional cyclists (n = 18) from two teams were recruited to participate in the research. They were divided into 2 groups: the control group (n = 9) and the magnesium-supplemented group (n = 9). The supplementation consisted of an intake of 400 mg/day of magnesium during the 3 weeks of competition. Blood samples were collected according to World Anti-Doping Agency rules at three specific moments during competition: immediately before the race; mid competition; and before the last stage. Levels of serum and erythrocyte magnesium, lactate dehydrogenase, creatinine kinase, aspartate transaminase, alanine transaminase, myoglobin, aldolase, total proteins, cortisol and creatinine were determined. Serum and erythrocyte magnesium levels decreased during the race. Circulating tissue markers increased at the end of the race in both groups. However, myoglobin increase was mitigated in the supplemented group compared with the controls. We conclude that magnesium supplementation seems to exert a protective effect on muscle damage.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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