The association of red meat intake with inflammation and circulating intermediate biomarkers of type 2 diabetes is mediated by central adiposity
Mazidi M, Kengne AP, George ES, Siervo M
The British journal of nutrition · 31 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2019-08-22 · Br J Nutr · vol. 125 · issue 9 · pp. 1043–1050
- Publisher
- Cambridge University Press
- Cited
- 39 citations · more than 95% of similar papers · 4.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 65 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Diet and metabolism studies · Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Insulin resistance, Internal medicine, Waist, Medicine, Endocrinology, National Health and Nutrition Examination Survey, Adipose tissue, Type 2 diabetes, C-reactive protein, Red meat, Mediation, Inflammation, Glycated hemoglobin, Diabetes mellitus, Obesity, Population, Environmental health, Pathology
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, inflammation, blood glucose, lipids, triglycerides, c-reactive protein, apolipoproteins b, body mass index, diet, nutrition surveys, adult, middle aged, female, male, intra-abdominal fat, adiposity, waist circumference, obesity, abdominal, biomarkers, red meat, glycated hemoglobin
4 authors
From ZA, AU, GB
- Mohsen Mazidi · correspondingSouth African Medical Research Council; University of Cape Town
- André Pascal KengneSouth African Medical Research Council; University of Cape Town
- Elena S. GeorgeDeakin University
- Mario SiervoUniversity of Nottingham; Queen's Medical Centre
Abstract
We explored the role of lipid accumulation products and visceral adiposity on the association between red meat consumption (RMC) and markers of insulin resistance (IR) and inflammation in USA adults. Data on RMC and health outcome measurements were extracted from the 2005-2010 US National Health and Nutrition Examination Surveys. Overall 16 621 participants were included in the analysis (mean age = 47·1 years, 48·3 % men). ANCOVA and 'conceptus causal mediation' models were applied while accounting for survey design. In adjusted models, a lower RMC was significantly associated with a cardio-protective profile of IR and inflammation. BMI had significant mediation effects on the association between RMC and C-reactive protein (CRP), apo B, fasting blood glucose (FBG), insulin, homoeostatic model assessment of IR and β-cell function, glycated Hb (HbA1c), TAG:HDL ratio and TAG glucose (TyG) index (all Ps < 0·05). Both waist circumference and anthropometrically predicted visceral adipose tissue mediated the association between RMC and CRP, FBG, HbA1c, TAG:HDL ratio and TyG index (all Ps < 0·05). Our findings suggest that adiposity, particularly the accumulation of abdominal fat, accounts for a significant proportion of the associations between red meat consumption, IR and inflammation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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