Acute Respiratory Tract Infection and 25-Hydroxyvitamin D Concentration: A Systematic Review and Meta-Analysis
Pham H, Rahman A, Majidi A, Waterhouse M, Neale RE
International journal of environmental research and public health · 95 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of Queensland
- Government
- National Health and Medical Research Council
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-08-21 · Int J Environ Res Public Health · vol. 16 · issue 17 · p. 3020
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 141 citations · more than 96% of similar papers · 4.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 56 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Asthma and respiratory diseases · Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- Meta-analysis, Confidence interval, Odds ratio, Vitamin D and neurology, Medicine, Internal medicine, Respiratory tract infections, Observational study, Gastroenterology, vitamin D deficiency, Respiratory system
- MeSH
- humans, respiratory tract infections, acute disease, vitamins, vitamin d, observational studies as topic
5 authors
From AU
- Hai D. Pham · correspondingThe University of Queensland; QIMR Berghofer Medical Research Institute
- Aninda RahmanThe University of Queensland; QIMR Berghofer Medical Research Institute
- Azam MajidiThe University of Queensland; QIMR Berghofer Medical Research Institute
- Mary A. WaterhouseQIMR Berghofer Medical Research Institute
- Rachel E. NealeThe University of Queensland; QIMR Berghofer Medical Research Institute
Abstract
Observational studies and randomised controlled studies suggest that vitamin D plays a role in the prevention of acute respiratory tract infection (ARTI); however, findings are inconsistent and the optimal serum 25-hydroxyvitamin D (25(OH)D) concentration remains unclear. To review the link between 25(OH)D concentration and ARTI, we searched PubMed and EMBASE databases to identify observational studies reporting the association between 25(OH)D concentration and risk or severity of ARTI. We used random-effects meta-analysis to pool findings across studies. Twenty-four studies were included in the review, 14 were included in the meta-analysis of ARTI risk and five in the meta-analysis of severity. Serum 25(OH)D concentration was inversely associated with risk and severity of ARTI; pooled odds ratios (95% confidence interval) were 1.83 (1.42-2.37) and 2.46 (1.65-3.66), respectively, comparing the lowest with the highest 25(OH)D category. For each 10 nmol/L decrease in 25(OH)D concentration, the odds of ARTI increased by 1.02 (0.97-1.07). This was a non-linear trend, with the sharpest increase in risk of ARTI occurring at 25(OH)D concentration < 37.5 nmol/L. In conclusion, there is an inverse non-linear association between 25(OH)D concentration and ARTI.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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