The Effect of Magnesium Intake on Stroke Incidence: A Systematic Review and Meta-Analysis With Trial Sequential Analysis
Zhao B, Hu L, Dong Y, Xu J, Wei Y, Yu D, Xu J, Zhang W
Frontiers in neurology · 23 citations
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- University or hospital
- Chinese Academy of Medical Sciences
- University or hospital
- Peking Union Medical College Hospital
- University or hospital
- Peking Union Medical College
- Grants
- National Natural Science Foundation of China (81560345)
Based on 4 listed funder(s).
Publication
- Published
- 2019-08-07 · Front Neurol · vol. 10 · p. 852
- Publisher
- Frontiers Media
- Cited
- 35 citations · more than 62% of similar papers · 0.7× the field average
- References
- 30 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Cardiovascular Health and Disease Prevention · Sodium Intake and Health
- Keywords
- Medicine, Stroke (engine), Relative risk, Meta-analysis, Cochrane Library, Internal medicine, Incidence (geometry), Magnesium, Prospective cohort study, Intracerebral hemorrhage, Cohort study, Subarachnoid hemorrhage, Surgery, Confidence interval
8 authors
From CN
- Binghao ZhaoNanchang University; Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital; First Affiliated Hospital of Nanchang University
- Lei HuNanchang University; Second Affiliated Hospital of Nanchang University
- Yifei DongNanchang University; Second Affiliated Hospital of Nanchang University
- Jingsong XuNanchang University; Second Affiliated Hospital of Nanchang University; First Affiliated Hospital of Nanchang University
- Yiping WeiNanchang University; First Affiliated Hospital of Nanchang University
- Dongliang YuNanchang University; First Affiliated Hospital of Nanchang University
Abstract
Background: The effect of magnesium on stroke has been consistently discussed less, and the results of previous studies have been contradictory. We reviewed the latest literature and quantified robust evidence of the association between magnesium intake and stroke risk. Methods: PubMed, EMBASE, the Cochrane Library, the Web of Science and ClinicalTrials.gov were searched through inception to January 15, 2019 for prospective cohort studies on magnesium intake and the incidence of stroke. Results: Fifteen studies with low bias involving 18 cohorts were entered into this study. The summary relative risk (RR) was significantly reduced by 11% for total stroke (RR: 0.89 [95% CI, 0.83-0.94]; P P = 0.001), comparing the highest magnesium intake category to the lowest. After adjusting for calcium intake, the inverse association still existed for total stroke (RR: 0.89 ([95% CI, 0.80-0.99]; P = 0.040). There was an inverse but non-significant association for hemorrhagic stroke, subarachnoid hemorrhage and intracerebral hemorrhage. The quantitative associations for total and ischemic stroke were robust. Importantly, high-risk females who had a body mass index (BMI) ≥25 kg/m2 and who were subjected to a ≥12 y follow-up exhibited a greater decrease in RRs as a result of magnesium intake. For each 100 mg/day increase in magnesium, the risk for total stroke was reduced by 2% and the risk for ischemic stroke was reduced by 2%. Conclusions: Increasing magnesium intake may be a crucial component of stroke prevention that acts in a dose-dependent manner. However, the conclusion is limited by the observational nature of the studies examined, and further randomized controlled trials are still needed.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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