Effect of omega-3 fatty acids and fish oil supplementation on multiple sclerosis: a systematic review
AlAmmar WA, Albeesh FH, Ibrahim LM, Algindan YY, Yamani LZ, Khattab RY
Nutritional neuroscience · 85 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2019-08-28 · Nutr Neurosci · vol. 24 · issue 7 · pp. 569–579
- Publisher
- Taylor & Francis
- Cited
- 117 citations · more than 87% of similar papers · 2.0× the field average
- References
- 37 works
- Access
- Paywalled
- Research areas
- Multiple Sclerosis Research Studies · Fatty Acid Research and Health · Pediatric health and respiratory diseases
- Keywords
- Fish oil, Multiple sclerosis, Medicine, Polyunsaturated fatty acid, Randomized controlled trial, Internal medicine, Physiology, Fish <Actinopterygii>, Gastroenterology, Bioinformatics, Biology, Fatty acid, Immunology, Biochemistry
- MeSH
- humans, multiple sclerosis, fatty acids, omega-3, fish oils, dietary supplements, female, male
6 authors
From SA
- Welayah Ali AlAmmarImam Abdulrahman Bin Faisal University
- Fatima H. AlbeeshImam Abdulrahman Bin Faisal University
- Layla Makki IbrahimImam Abdulrahman Bin Faisal University
- Yasmin AlgindanImam Abdulrahman Bin Faisal University
- Lamya Zohair YamaniImam Abdulrahman Bin Faisal University
- Rabie Yousif Khattab · correspondingImam Abdulrahman Bin Faisal University
Abstract
Background: Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system, resulting in the degradation of the myelin sheath. Diet especially fish oils and omega-3 has been found to play an important role in MS. This work aimed to review the literature systematically for evidence on the effect of omega-3 fatty acids (EPA, DPA and DHA) on MS progression in adults.Methods: The literature search was conducted in PubMed, Oxford, Cochrane, Embase, International pharmaceutical abstract, PsychINFO, and clinical trials government. The inclusions were studies performed on humans both male and female, aged 18 years at minimum, diagnosed with MS according to McDonald 2010 criteria. Otherwise, all studies were excluded.Results: A total of 5554 studies were screened and seven were thoroughly focused on as they typically met the inclusion criteria. These studies showed the beneficial roles of fish oil supplementation and omega-3 fatty acids in improving the quality of life of MS patients. These roles were attributed to their beneficial effects on inflammatory markers, glutathione reductase, reducing the relapsing rate, and achieving balanced omega-6 to omega-3 ratios.Conclusion: Omega-3 and fish oils supplementations have beneficial effects on reducing the relapsing rate, inflammatory markers, and improving the quality of life for MS patients.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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