Associations between calcium and magnesium intake and the risk of incident gastric cancer: A prospective cohort analysis of the National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study
Shah SC, Dai Q, Zhu X, Peek RM, Smalley W, Roumie C, Shrubsole MJ
International journal of cancer · 27 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- Patient-Centered Outcomes Research Institute
- Government
- Rural Development Administration
- Government
- National Institutes of Health
- Government
- Agency for Healthcare Research and Quality
- Government
- National Cancer Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NCI NIH HHS
- Government
- NIDDK NIH HHS
- Government
- AHRQ HHS
- Grants
- National Cancer Institute (P01 CA-116087); Agency for Healthcare Research and Quality (K12 HS026395); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK-058404); National Cancer Institute (R01 CA077955); National Institutes of Health (K12 HS026395); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK058587); Agency for Healthcare Research and Quality (HS026395)
Based on 9 listed funder(s).
Publication
- Published
- 2019-08-31 · Int J Cancer · vol. 146 · issue 11 · pp. 2999–3010
- Publisher
- Wiley
- Cited
- 33 citations · more than 77% of similar papers · 1.2× the field average
- References
- 46 works
- Access
- Free to read
- Research areas
- Magnesium in Health and Disease · Esophageal and GI Pathology · Parathyroid Disorders and Treatments
- Keywords
- Medicine, Prospective cohort study, Cohort study, Cohort, Cancer, Internal medicine, Environmental health, Gerontology
- MeSH
- cardia, humans, adenocarcinoma, stomach neoplasms, calcium, dietary, magnesium, diet, cohort studies, prospective studies, nutritional status, dietary supplements, middle aged, united states, female, male, surveys and questionnaires
7 authors
From US
- Shailja C. Shah · correspondingVA Tennessee Valley Healthcare System; Vanderbilt University Medical Center
- Qi DaiVanderbilt University Medical Center
- Xiangzhu ZhuVanderbilt University Medical Center
- Richard M. PeekVanderbilt University Medical Center
- Walter E. SmalleyVanderbilt University; VA Tennessee Valley Healthcare System; Vanderbilt Health; Vanderbilt University Medical Center
- Christianne L. RoumieVA Tennessee Valley Healthcare System; Vanderbilt University Medical Center
Abstract
Gastric cancer remains a leading cause of cancer-related mortality. Identifying dietary and other modifiable disease determinants has important implications for risk attenuation in susceptible individuals. Our primary aim was to estimate the association between dietary and supplemental intakes of calcium and magnesium and the risk of incident gastric cancer. We conducted a prospective cohort analysis of the National Institutes of Health-American Association of Retired Persons Diet and Health Study. We used Cox proportional hazard modeling to estimate the association between calcium and magnesium intakes with risk of incident gastric adenocarcinoma (GA) overall and by anatomic location, noncardia GA (NCGA) and cardia GA (CGA). A total of 536,403 respondents (59% males, 41% females) were included for analysis, among whom 1,518 incident GAs (797 NCGA and 721 CGA) occurred. Increasing calcium intake was associated with lower risk of GA overall (p-trend = 0.05), driven primarily by the association with NCGA, where the above median calcium intakes were associated with a 23% reduction in risk compared to the lowest quartile (p-trend = 0.05). This magnitude of NCGA risk reduction was greater among nonwhite ethnic group and Hispanics (hazard ratio [HR] 0.51, 95% confidence interval [CI]: 0.24-1.07, p-trend = 0.04), current/former smokers (HR 0.58, 95% CI: 0.41-0.81), obese individuals (HR 0.54, 95% CI: 0.31-0.96) and those with high NCGA risk scores (HR 0.50, 95% CI: 0.31-0.80). Among men only, increasing magnesium intake was associated with 22-27% reduced risk of NCGA (p-trend = 0.05), while for the cohort, dietary magnesium intake in the highest vs. lowest quartile was associated with a 34% reduced risk of NCGA (HR 0.66, 95% CI: 0.48-0.90). These findings have important implications for risk factor modification. Future investigations are needed not only to confirm our results, but to define mechanisms underlying these associations.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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