Omega-3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials
Avallone R, Vitale G, Bertolotti M
International journal of molecular sciences · 138 citations
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Office of Dietary Supplements
- Nonprofit
- Fondazione Cassa di Risparmio di Modena
- Government
- National Institutes of Health
- Grants
- Fondazione Cassa di Risparmio di Modena (Grant n.2018.0334); Fondazione Cassa di Risparmio di Modena (2018.0334)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-08-30 · Int J Mol Sci · vol. 20 · issue 17 · p. 4256
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 201 citations · more than 100% of similar papers · 13.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 84 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Fatty Acid Research and Health · Folate and B Vitamins Research · Antioxidant Activity and Oxidative Stress
- Keywords
- Disease, Clinical trial, Polyunsaturated fatty acid, Medicine, Bioinformatics, Neuroscience, Biology, Biochemistry, Fatty acid, Internal medicine
- MeSH
- humans, neurodegenerative diseases, fatty acids, omega-3, clinical trials as topic, observational studies as topic
3 authors
From IT
- Rossella Avallone · correspondingUniversity of Modena and Reggio Emilia
- Giovanni VitaleUniversity of Modena and Reggio Emilia
- Marco BertolottiUniversity of Modena and Reggio Emilia
Abstract
A nutritional approach could be a promising strategy to prevent or slow the progression of neurodegenerative diseases such as Parkinson's and Alzheimer's disease, since there is no effective therapy for these diseases so far. The beneficial effects of omega-3 fatty acids are now well established by a plethora of studies through their involvement in multiple biochemical functions, including synthesis of anti-inflammatory mediators, cell membrane fluidity, intracellular signaling, and gene expression. This systematic review will consider epidemiological studies and clinical trials that assessed the impact of supplementation or dietary intake of omega-3 polyunsaturated fatty acids on neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. Indeed, treatment with omega-3 fatty acids, being safe and well tolerated, represents a valuable and biologically plausible tool in the management of neurodegenerative diseases in their early stages.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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